Visceral and neural larva migrans in rhesus macaques

Alfonso S. Gozalo, Olga A. Maximova, Marisa C. St. Claire, Richard J. Montali, Jerrold M. Ward, Lily I. Cheng, William R. Elkins, Kevin R. Kazacos

Research output: Contribution to journalArticle

Abstract

Large ascarid larvae within granulomas were noted histologically in the mesenteric and pancreatic lymph nodes of 13 of 21 rhesus macaques (Macaca mulatta) euthanized as part of an experimental viral pathogenesis study. In addition, 7 of the 13 monkeys had cerebral granulomas, which in 4 animals contained nematode larvae similar to those within the lymph nodes. Despite the lesions, the animals did not show clinical signs associated with the parasitic infections. Characteristics of the larvae included, on cross-section, a midbody diameter of approximately 60 to 80 μm, a centrally located and slightly compressed intestine flanked on either side by large triangular excretory columns, and prominent single lateral cuticular alae. The morphology of the larvae was compatible with Baylisascaris spp. Baylisascariasis is a well-described infection of animals and humans that is caused by migrating larvae of the raccoon roundworm, Baylisascaris procyonis. A similar species, B. columnaris, is found in skunks and can cause cerebrospinal nematodiasis, but most reported cases of baylisascariasis have been due to B. procyonis. Our macaques were born free-ranging on an island in the southeastern United States where raccoons, but not skunks, were found to be common inhabitants, indicating that B. procyonis was the most likely parasite involved. These cases are similar to the low-level or covert cases of Baylisascaris infection described to occur in humans and provide further evidence of the existence of this parasite in the southeastern United States.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalJournal of the American Association for Laboratory Animal Science
Volume47
Issue number4
StatePublished - Jul 2008

Fingerprint

Baylisascaris procyonis
larva migrans
Macaca mulatta
Baylisascaris
skunks
larvae
granuloma
Southeastern United States
lymph nodes
Ascarididae
parasites
animals
Procyon lotor
nematode larvae
parasitoses
Macaca
lesions (animal)
infection
monkeys
intestines

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Gozalo, A. S., Maximova, O. A., St. Claire, M. C., Montali, R. J., Ward, J. M., Cheng, L. I., ... Kazacos, K. R. (2008). Visceral and neural larva migrans in rhesus macaques. Journal of the American Association for Laboratory Animal Science, 47(4), 64-67.

Visceral and neural larva migrans in rhesus macaques. / Gozalo, Alfonso S.; Maximova, Olga A.; St. Claire, Marisa C.; Montali, Richard J.; Ward, Jerrold M.; Cheng, Lily I.; Elkins, William R.; Kazacos, Kevin R.

In: Journal of the American Association for Laboratory Animal Science, Vol. 47, No. 4, 07.2008, p. 64-67.

Research output: Contribution to journalArticle

Gozalo, AS, Maximova, OA, St. Claire, MC, Montali, RJ, Ward, JM, Cheng, LI, Elkins, WR & Kazacos, KR 2008, 'Visceral and neural larva migrans in rhesus macaques', Journal of the American Association for Laboratory Animal Science, vol. 47, no. 4, pp. 64-67.
Gozalo AS, Maximova OA, St. Claire MC, Montali RJ, Ward JM, Cheng LI et al. Visceral and neural larva migrans in rhesus macaques. Journal of the American Association for Laboratory Animal Science. 2008 Jul;47(4):64-67.
Gozalo, Alfonso S. ; Maximova, Olga A. ; St. Claire, Marisa C. ; Montali, Richard J. ; Ward, Jerrold M. ; Cheng, Lily I. ; Elkins, William R. ; Kazacos, Kevin R. / Visceral and neural larva migrans in rhesus macaques. In: Journal of the American Association for Laboratory Animal Science. 2008 ; Vol. 47, No. 4. pp. 64-67.
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