Virus-specific cytotoxic T lymphocytes in multiple sclerosis: a normal mumps virus response adds support for a distinct impairment in the measles virus response

Andrew D. Goodman, Steven Jacobson, Henry F. McFarland

Research output: Contribution to journalArticle

Abstract

An impairment of the measles virus-specific cytotoxic T lymphocyte response in multiple sclerosis was previously reported. This response is predominantly mediated by HLA class II-restricted CD4+ cells. In the present report, virus-specific cytotoxic T lymphocyte responses in multiple sclerosis were further studied by examining the response to mump virus. No significant difference was detected in the generation of mumps virus-specific cytotoxic T lymphocyte responses between normal individuals and multiple sclerosis patients with impaired measles virus-specific cytotoxicity. A portion of the mumps virus-specific cytotoxic T lymphocyte response could be mediated by HLA class II-restricted CD4+ cells generated from both normal controls and MS patients. This CD4+ cell-mediated portion of the response was similar in both groups. These findings support the view that there is a distinct measles virus-specific impairment in cell-mediated cytotoxicity in multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalJournal of Neuroimmunology
Volume22
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Cytotoxic T lymphocyte
  • Measles virus
  • Multiple sclerosis
  • Mumps virus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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