Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication to interferon production

Sinnie Sin Man Ng; Tsung Hsien Chang; Prafullakumar Tailor; Keiko Ozato; Tomoshige Kino

doi:10.1016/j.febslet.2011.04.001

Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication to interferon production

Sinnie Sin Man Ng, Tsung Hsien Chang, Prafullakumar Tailor, Keiko Ozato, Tomoshige Kino

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in mouse bone marrow-derived dendritic cells (DCs) upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels. Exogenous expression of the latter NRs repressed IRF3- or IRF7-induced transactivation of the interferon β promoter and NDV infection further potentiated their repressive effect. The viral infection also significantly regulated mRNA expression of some coregulators, including HDAC1. Toll-like receptor ligands regulated NR and coregulator mRNA expression similar to the viruses. Thus, NRs and coregulators are integral components of DC-organizing anti-viral response wherein NOR1 and LXRα participate in regulating interferon production.

Original language	English (US)
Pages (from-to)	1331-1337
Number of pages	7
Journal	FEBS Letters
Volume	585
Issue number	9
DOIs	https://doi.org/10.1016/j.febslet.2011.04.001
State	Published - May 6 2011
Externally published	Yes

Keywords

Coregulator
Dendritic cell
Histone deacetylase
Neuron-derived orphan receptor-1
Nuclear receptor
Viral infection

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2011.04.001

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title = "Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication to interferon production",

abstract = "We investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in mouse bone marrow-derived dendritic cells (DCs) upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels. Exogenous expression of the latter NRs repressed IRF3- or IRF7-induced transactivation of the interferon β promoter and NDV infection further potentiated their repressive effect. The viral infection also significantly regulated mRNA expression of some coregulators, including HDAC1. Toll-like receptor ligands regulated NR and coregulator mRNA expression similar to the viruses. Thus, NRs and coregulators are integral components of DC-organizing anti-viral response wherein NOR1 and LXRα participate in regulating interferon production.",

keywords = "Coregulator, Dendritic cell, Histone deacetylase, Neuron-derived orphan receptor-1, Nuclear receptor, Viral infection",

author = "Ng, {Sinnie Sin Man} and Chang, {Tsung Hsien} and Prafullakumar Tailor and Keiko Ozato and Tomoshige Kino",

note = "Funding Information: This study was funded by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development , National Institutes of Health. ",

year = "2011",

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doi = "10.1016/j.febslet.2011.04.001",

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T1 - Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells

T2 - Implication to interferon production

AU - Ng, Sinnie Sin Man

AU - Chang, Tsung Hsien

AU - Tailor, Prafullakumar

AU - Ozato, Keiko

AU - Kino, Tomoshige

N1 - Funding Information: This study was funded by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development , National Institutes of Health.

PY - 2011/5/6

Y1 - 2011/5/6

N2 - We investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in mouse bone marrow-derived dendritic cells (DCs) upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels. Exogenous expression of the latter NRs repressed IRF3- or IRF7-induced transactivation of the interferon β promoter and NDV infection further potentiated their repressive effect. The viral infection also significantly regulated mRNA expression of some coregulators, including HDAC1. Toll-like receptor ligands regulated NR and coregulator mRNA expression similar to the viruses. Thus, NRs and coregulators are integral components of DC-organizing anti-viral response wherein NOR1 and LXRα participate in regulating interferon production.

AB - We investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in mouse bone marrow-derived dendritic cells (DCs) upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels. Exogenous expression of the latter NRs repressed IRF3- or IRF7-induced transactivation of the interferon β promoter and NDV infection further potentiated their repressive effect. The viral infection also significantly regulated mRNA expression of some coregulators, including HDAC1. Toll-like receptor ligands regulated NR and coregulator mRNA expression similar to the viruses. Thus, NRs and coregulators are integral components of DC-organizing anti-viral response wherein NOR1 and LXRα participate in regulating interferon production.

KW - Coregulator

KW - Dendritic cell

KW - Histone deacetylase

KW - Neuron-derived orphan receptor-1

KW - Nuclear receptor

KW - Viral infection

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Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication to interferon production

Abstract

Keywords

ASJC Scopus subject areas

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