Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections

Yvonne J. Rosenberg, Aurelio Cafaro, Terry Brennan, Jack G. Greenhouse, Francois Villinger, Aftab A. Ansari, Charles Brown, Kathy McKinnon, Sharon Bellah, Jacob Yalley-Ogunro, William R. Elkins, Suzanne Gartner, Mark G. Lewis

Research output: Contribution to journalArticle

Abstract

Decline in blood CD4+ lymphocytes during primary symptomatic infections with HIV is usually attributed to viral killing, and has not been considered in terms of altered lymphocyte migration and sequestration. We therefore sought to examine whether CD4+ cell loss from blood of macaques undergoing an acute primary SIV infection might be due to increased synthesis of cytokines, known to profoundly affect lymphocyte trafficking, rather than to direct lymphocyte destruction by virus. The findings indicate that rapid lymphocyte depletion following acute infection is not selective for CD4+ cells, correlates precisely with increased plasma IFN-γ and tumor necrosis factor-α levels, and is reversible. CD4/CD8 ratios in lymph nodes with high viral burdens remain relatively unchanged despite lymphocyte loss from blood. Levels of cytokine mRNA measured in lymphoid organs reflect neither cytokine plasma levels nor their potential to induce sequestration. These results support a model of cytokine-induced lymphocyte extravasation to account for the acute HIV/SIV-induced CD4+ cell lymphopenia and raise questions regarding the extent to which altered lymphocyte migration plays a role in the gradual CD4+ cell depletion throughout infection.

Original languageEnglish (US)
Pages (from-to)703-712
Number of pages10
JournalInternational Immunology
Volume9
Issue number5
DOIs
StatePublished - 1997

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Lymphocytes
Cytokines
Viruses
Infection
Lymphocyte Depletion
CD4-CD8 Ratio
Lymphopenia
Macaca
Viral Load
HIV Infections
Blood Cells
Tumor Necrosis Factor-alpha
Lymph Nodes
HIV
Messenger RNA

Keywords

  • IFN-γ
  • Lymphopenia
  • Sequestration
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Immunology

Cite this

Rosenberg, Y. J., Cafaro, A., Brennan, T., Greenhouse, J. G., Villinger, F., Ansari, A. A., ... Lewis, M. G. (1997). Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections. International Immunology, 9(5), 703-712. https://doi.org/10.1093/intimm/9.5.703

Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections. / Rosenberg, Yvonne J.; Cafaro, Aurelio; Brennan, Terry; Greenhouse, Jack G.; Villinger, Francois; Ansari, Aftab A.; Brown, Charles; McKinnon, Kathy; Bellah, Sharon; Yalley-Ogunro, Jacob; Elkins, William R.; Gartner, Suzanne; Lewis, Mark G.

In: International Immunology, Vol. 9, No. 5, 1997, p. 703-712.

Research output: Contribution to journalArticle

Rosenberg, YJ, Cafaro, A, Brennan, T, Greenhouse, JG, Villinger, F, Ansari, AA, Brown, C, McKinnon, K, Bellah, S, Yalley-Ogunro, J, Elkins, WR, Gartner, S & Lewis, MG 1997, 'Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections', International Immunology, vol. 9, no. 5, pp. 703-712. https://doi.org/10.1093/intimm/9.5.703
Rosenberg YJ, Cafaro A, Brennan T, Greenhouse JG, Villinger F, Ansari AA et al. Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections. International Immunology. 1997;9(5):703-712. https://doi.org/10.1093/intimm/9.5.703
Rosenberg, Yvonne J. ; Cafaro, Aurelio ; Brennan, Terry ; Greenhouse, Jack G. ; Villinger, Francois ; Ansari, Aftab A. ; Brown, Charles ; McKinnon, Kathy ; Bellah, Sharon ; Yalley-Ogunro, Jacob ; Elkins, William R. ; Gartner, Suzanne ; Lewis, Mark G. / Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections. In: International Immunology. 1997 ; Vol. 9, No. 5. pp. 703-712.
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