Virtual Cortical Stimulation Mapping of Epilepsy Networks to Localize the Epileptogenic Zone

Adam Li, Zachary Fitzgerald, Jennifer Hopp, Emily Johnson, Nathan Crone, Juan Bulacio, Jorge Martinez-Gonzalez, Sara Inati, Kareem Zaghloul, Sridevi V. Sarma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cortical stimulation mapping (CSM) is a common clinical procedure for mapping eloquent cortex in epilepsy patients. Electrical responses to the stimulation, or after-discharges (ADs), that occur in response to stimulation can point to unstable regions of cortex that are more prone to spontaneous seizures. Clinicians are interested in identifying regions that start seizures, i.e., the epileptogenic zone (EZ), so that they can target treatment. However, during CSM, not all regions are stimulated, as it would be time-consuming and potentially harmful to the patient. This limits the clinician's ability to fully explore ADs to reliably localize the EZ. In this paper, we develop a virtual CSM procedure that processes pre-seizure intracranial EEG recordings obtained from epilepsy patients being treated at three different epilepsy centers. First, we identify a linear time varying network (LTVN) model from electrocorticography (ECoG) and stereo-EEG (SEEG) data using sparse least squares estimation for each patient. We then construct an virtual CSM by applying impulse perturbations to each electrode contact in the LTVN model and then measuring the ADs of the network. We summarize the l2-norm of the responses in the form of a heatmap that shows the spatio-temporal evolution of the ADs before, during, and after seizures. Finally we compute an impulse response ratio (IRR) metric from each heatmap, that measures the ratio between the mean norm of ADs of clinically annotated EZ contacts and the mean norm of ADs of the remaining contacts. We find that the IRR is higher in maps derived from patients with successful surgical outcomes and lower in failed surgical outcomes. This suggests that virtual CSM may provide valuable information to clinicians regarding EZ location.

Original languageEnglish (US)
Title of host publication2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2328-2331
Number of pages4
ISBN (Electronic)9781538613115
DOIs
StatePublished - Jul 2019
Event41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Germany
Duration: Jul 23 2019Jul 27 2019

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
CountryGermany
CityBerlin
Period7/23/197/27/19

Fingerprint

Epilepsy
Seizures
Time varying networks
Linear networks
Electroencephalography
Impulse response
Least-Squares Analysis
Electrodes
Electrocorticography
Therapeutics

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Li, A., Fitzgerald, Z., Hopp, J., Johnson, E., Crone, N., Bulacio, J., ... Sarma, S. V. (2019). Virtual Cortical Stimulation Mapping of Epilepsy Networks to Localize the Epileptogenic Zone. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (pp. 2328-2331). [8856591] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2019.8856591

Virtual Cortical Stimulation Mapping of Epilepsy Networks to Localize the Epileptogenic Zone. / Li, Adam; Fitzgerald, Zachary; Hopp, Jennifer; Johnson, Emily; Crone, Nathan; Bulacio, Juan; Martinez-Gonzalez, Jorge; Inati, Sara; Zaghloul, Kareem; Sarma, Sridevi V.

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 2328-2331 8856591 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Li, A, Fitzgerald, Z, Hopp, J, Johnson, E, Crone, N, Bulacio, J, Martinez-Gonzalez, J, Inati, S, Zaghloul, K & Sarma, SV 2019, Virtual Cortical Stimulation Mapping of Epilepsy Networks to Localize the Epileptogenic Zone. in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019., 8856591, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 2328-2331, 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019, Berlin, Germany, 7/23/19. https://doi.org/10.1109/EMBC.2019.8856591
Li A, Fitzgerald Z, Hopp J, Johnson E, Crone N, Bulacio J et al. Virtual Cortical Stimulation Mapping of Epilepsy Networks to Localize the Epileptogenic Zone. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 2328-2331. 8856591. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2019.8856591
Li, Adam ; Fitzgerald, Zachary ; Hopp, Jennifer ; Johnson, Emily ; Crone, Nathan ; Bulacio, Juan ; Martinez-Gonzalez, Jorge ; Inati, Sara ; Zaghloul, Kareem ; Sarma, Sridevi V. / Virtual Cortical Stimulation Mapping of Epilepsy Networks to Localize the Epileptogenic Zone. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 2328-2331 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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