TY - JOUR
T1 - Virtual clinical trials in medical imaging
T2 - A review
AU - Abadi, Ehsan
AU - Segars, William P.
AU - Tsui, Benjamin M.W.
AU - Kinahan, Paul E.
AU - Bottenus, Nick
AU - Frangi, Alejandro F.
AU - Maidment, Andrew
AU - Lo, Joseph
AU - Samei, Ehsan
N1 - Publisher Copyright:
© 2020 Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2020/7/1
Y1 - 2020/7/1
N2 - The accelerating complexity and variety of medical imaging devices and methods have outpaced the ability to evaluate and optimize their design and clinical use. This is a significant and increasing challenge for both scientific investigations and clinical applications. Evaluations would ideally be done using clinical imaging trials. These experiments, however, are often not practical due to ethical limitations, expense, time requirements, or lack of ground truth. Virtual clinical trials (VCTs) (also known as in silico imaging trials or virtual imaging trials) offer an alternative means to efficiently evaluate medical imaging technologies virtually. They do so by simulating the patients, imaging systems, and interpreters. The field of VCTs has been constantly advanced over the past decades in multiple areas. We summarize the major developments and current status of the field of VCTs in medical imaging. We review the core components of a VCT: Computational phantoms, simulators of different imaging modalities, and interpretation models. We also highlight some of the applications of VCTs across various imaging modalities.
AB - The accelerating complexity and variety of medical imaging devices and methods have outpaced the ability to evaluate and optimize their design and clinical use. This is a significant and increasing challenge for both scientific investigations and clinical applications. Evaluations would ideally be done using clinical imaging trials. These experiments, however, are often not practical due to ethical limitations, expense, time requirements, or lack of ground truth. Virtual clinical trials (VCTs) (also known as in silico imaging trials or virtual imaging trials) offer an alternative means to efficiently evaluate medical imaging technologies virtually. They do so by simulating the patients, imaging systems, and interpreters. The field of VCTs has been constantly advanced over the past decades in multiple areas. We summarize the major developments and current status of the field of VCTs in medical imaging. We review the core components of a VCT: Computational phantoms, simulators of different imaging modalities, and interpretation models. We also highlight some of the applications of VCTs across various imaging modalities.
KW - computational phantoms
KW - in silico imaging
KW - medical imaging simulation
KW - simulations
KW - virtual clinical trials
KW - virtual imaging trials
UR - http://www.scopus.com/inward/record.url?scp=85091478305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85091478305&partnerID=8YFLogxK
U2 - 10.1117/1.JMI.7.4.042805
DO - 10.1117/1.JMI.7.4.042805
M3 - Article
C2 - 32313817
AN - SCOPUS:85091478305
SN - 2329-4302
VL - 7
JO - Journal of Medical Imaging
JF - Journal of Medical Imaging
IS - 4
M1 - 042805
ER -