Viral versus cellular bcl-2 proteins

J. M. Hardwick, D. S. Bellows

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2.Gammaherpesviruses are associatedwith human and animal lymphoid and epithelial tumours. However, the role of these viral BCL-2 homologues in the virus replication cycle or in human disease is not known, though recent developments showprogress in this area. The structure of viral BCL-2 family protein, KSBcl-2, is similar to that of cellular family members, but viral BCL-2 proteins differ functionally from the cellular proteins, apparently escaping the regulatory mechanisms to which their cellular counterparts are subjected. Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin.

Original languageEnglish (US)
Pages (from-to)S68-S76
JournalCell death and differentiation
StatePublished - 2003


  • Bax
  • Bcl-2
  • Bhrf1
  • Epstein-Barr virus (ebv)
  • Herpesvirus
  • Kaposi's sarcoma-associated herpesvirus (KSHV)
  • Ksbcl-2
  • Virus

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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