Viral versus cellular bcl-2 proteins

J. M. Hardwick; D. S. Bellows

doi:10.1038/sj.cdd.4401133

Viral versus cellular bcl-2 proteins

J. M. Hardwick, D. S. Bellows

Bloomberg School of Public Health

Research output: Contribution to journal › Review article

Abstract

All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2.Gammaherpesviruses are associatedwith human and animal lymphoid and epithelial tumours. However, the role of these viral BCL-2 homologues in the virus replication cycle or in human disease is not known, though recent developments showprogress in this area. The structure of viral BCL-2 family protein, KSBcl-2, is similar to that of cellular family members, but viral BCL-2 proteins differ functionally from the cellular proteins, apparently escaping the regulatory mechanisms to which their cellular counterparts are subjected. Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin.

Original language	English (US)
Pages (from-to)	S68-S76
Journal	Cell death and differentiation
Volume	10
DOIs	https://doi.org/10.1038/sj.cdd.4401133
State	Published - Jan 1 2003

Keywords

Bax
Bcl-2
Bhrf1
Epstein-Barr virus (ebv)
Herpesvirus
Kaposi's sarcoma-associated herpesvirus (KSHV)
Ksbcl-2
Virus

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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Hardwick, J. M., & Bellows, D. S. (2003). Viral versus cellular bcl-2 proteins. Cell death and differentiation, 10, S68-S76. https://doi.org/10.1038/sj.cdd.4401133

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abstract = "All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2.Gammaherpesviruses are associatedwith human and animal lymphoid and epithelial tumours. However, the role of these viral BCL-2 homologues in the virus replication cycle or in human disease is not known, though recent developments showprogress in this area. The structure of viral BCL-2 family protein, KSBcl-2, is similar to that of cellular family members, but viral BCL-2 proteins differ functionally from the cellular proteins, apparently escaping the regulatory mechanisms to which their cellular counterparts are subjected. Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin.",

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