Viral versus cellular bcl-2 proteins

J. M. Hardwick; D. S. Bellows

doi:10.1038/sj.cdd.4401133

Viral versus cellular bcl-2 proteins

J. M. Hardwick, D. S. Bellows

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

Abstract

All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2.Gammaherpesviruses are associatedwith human and animal lymphoid and epithelial tumours. However, the role of these viral BCL-2 homologues in the virus replication cycle or in human disease is not known, though recent developments showprogress in this area. The structure of viral BCL-2 family protein, KSBcl-2, is similar to that of cellular family members, but viral BCL-2 proteins differ functionally from the cellular proteins, apparently escaping the regulatory mechanisms to which their cellular counterparts are subjected. Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin.

Original language	English (US)
Pages (from-to)	S68-S76
Journal	Cell death and differentiation
Volume	10
DOIs	https://doi.org/10.1038/sj.cdd.4401133
State	Published - 2003

Keywords

Bax
Bcl-2
Bhrf1
Epstein-Barr virus (ebv)
Herpesvirus
Kaposi's sarcoma-associated herpesvirus (KSHV)
Ksbcl-2
Virus

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/sj.cdd.4401133

Cite this

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title = "Viral versus cellular bcl-2 proteins",

abstract = "All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2.Gammaherpesviruses are associatedwith human and animal lymphoid and epithelial tumours. However, the role of these viral BCL-2 homologues in the virus replication cycle or in human disease is not known, though recent developments showprogress in this area. The structure of viral BCL-2 family protein, KSBcl-2, is similar to that of cellular family members, but viral BCL-2 proteins differ functionally from the cellular proteins, apparently escaping the regulatory mechanisms to which their cellular counterparts are subjected. Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin.",

keywords = "Bax, Bcl-2, Bhrf1, Epstein-Barr virus (ebv), Herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV), Ksbcl-2, Virus",

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language = "English (US)",

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issn = "1350-9047",

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AU - Hardwick, J. M.

AU - Bellows, D. S.

PY - 2003

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N2 - All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2.Gammaherpesviruses are associatedwith human and animal lymphoid and epithelial tumours. However, the role of these viral BCL-2 homologues in the virus replication cycle or in human disease is not known, though recent developments showprogress in this area. The structure of viral BCL-2 family protein, KSBcl-2, is similar to that of cellular family members, but viral BCL-2 proteins differ functionally from the cellular proteins, apparently escaping the regulatory mechanisms to which their cellular counterparts are subjected. Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin.

AB - All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2.Gammaherpesviruses are associatedwith human and animal lymphoid and epithelial tumours. However, the role of these viral BCL-2 homologues in the virus replication cycle or in human disease is not known, though recent developments showprogress in this area. The structure of viral BCL-2 family protein, KSBcl-2, is similar to that of cellular family members, but viral BCL-2 proteins differ functionally from the cellular proteins, apparently escaping the regulatory mechanisms to which their cellular counterparts are subjected. Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin.

KW - Bax

KW - Bcl-2

KW - Bhrf1

KW - Epstein-Barr virus (ebv)

KW - Herpesvirus

KW - Kaposi's sarcoma-associated herpesvirus (KSHV)

KW - Ksbcl-2

KW - Virus

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SP - S68-S76

JO - Cell Death and Differentiation

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Viral versus cellular bcl-2 proteins

Abstract

Keywords

ASJC Scopus subject areas

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