Viral vector biosafety in laboratory animal research

Dalis E. Collins, Jon D. Reuter, Howard G. Rush, Jason S. Villano

Research output: Contribution to journalReview article

Abstract

Viral vector research presents unique occupational health and safety challenges to institutions due to the rapid development of both in vivo and in vitro gene-editing technologies. Risks to human and animal health make it incumbent on institutions to appropriately evaluate viral vector usage in research on the basis of available information and governmental regulations and guidelines. Here we review the factors related to risk assessment regarding viral vector usage in animals and the relevant regulatory documents associated with this research, and we highlight the most commonly used viral vectors in research today. This review is particularly focused on the background, use in research and associated health and environmental risks related to adenoviral, adeno-associated viral, lentiviral, and herpesviral vectors.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalComparative medicine
Volume67
Issue number3
StatePublished - Jun 2017
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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  • Cite this

    Collins, D. E., Reuter, J. D., Rush, H. G., & Villano, J. S. (2017). Viral vector biosafety in laboratory animal research. Comparative medicine, 67(3), 215-221.