Viral replication and the coactivators p300 and CBP

Michael O. Hottiger, Gary J. Nabel

Research output: Contribution to journalArticle

Abstract

Productive viral infection requires coordinate regulation of viral and cellular gene expression. Viruses of different classes have evolved different mechanisms to conform to, adapt to and exploit programs of cellular gene expression. Many viral gene products influence and respond to cellular signals that control differentiation and proliferation Transcriptional coactivators are central to the regulation of the expression of genes controlling these events. p300 and CBP are closely related coactivators that regulate the transcription of specific genes, modify chromatin structure and influence cell cycle progression. In this review, the different molecular interactions of proteins encoded by DNA tumor viruses and lentiviruses with these transcriptional coactivators and related cellular proteins are summarized. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)560-565
Number of pages6
JournalTrends in Microbiology
Volume8
Issue number12
DOIs
StatePublished - Dec 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

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