TY - JOUR
T1 - Viral replication and the coactivators p300 and CBP
AU - Hottiger, Michael O.
AU - Nabel, Gary J.
PY - 2000/12/1
Y1 - 2000/12/1
N2 - Productive viral infection requires coordinate regulation of viral and cellular gene expression. Viruses of different classes have evolved different mechanisms to conform to, adapt to and exploit programs of cellular gene expression. Many viral gene products influence and respond to cellular signals that control differentiation and proliferation Transcriptional coactivators are central to the regulation of the expression of genes controlling these events. p300 and CBP are closely related coactivators that regulate the transcription of specific genes, modify chromatin structure and influence cell cycle progression. In this review, the different molecular interactions of proteins encoded by DNA tumor viruses and lentiviruses with these transcriptional coactivators and related cellular proteins are summarized. Copyright (C) 2000 Elsevier Science Ltd.
AB - Productive viral infection requires coordinate regulation of viral and cellular gene expression. Viruses of different classes have evolved different mechanisms to conform to, adapt to and exploit programs of cellular gene expression. Many viral gene products influence and respond to cellular signals that control differentiation and proliferation Transcriptional coactivators are central to the regulation of the expression of genes controlling these events. p300 and CBP are closely related coactivators that regulate the transcription of specific genes, modify chromatin structure and influence cell cycle progression. In this review, the different molecular interactions of proteins encoded by DNA tumor viruses and lentiviruses with these transcriptional coactivators and related cellular proteins are summarized. Copyright (C) 2000 Elsevier Science Ltd.
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U2 - 10.1016/S0966-842X(00)01874-6
DO - 10.1016/S0966-842X(00)01874-6
M3 - Article
C2 - 11115752
AN - SCOPUS:0034547922
SN - 0966-842X
VL - 8
SP - 560
EP - 565
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 12
ER -