Viral levels in newborn African infants undergoing primary HIV-1 infection

R. J. Biggar; R. Broadhead; M. Janes; N. Kumwenda; T. E.T. Taha; S. Cassol

doi:10.1097/00002030-200107060-00015

Viral levels in newborn African infants undergoing primary HIV-1 infection

R. J. Biggar, R. Broadhead, M. Janes, N. Kumwenda, T. E.T. Taha, S. Cassol

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We examined weekly changes in viral levels in seven untreated infants infected with HIV at birth. Viral levels spiked immediately but reverted quickly to plateau levels typical of infant HIV infection within 2 weeks of first detected viraemia. We speculated that the depletion of naive, susceptible cells is responsible for the rapid decrease in spike levels and that the rapid replacement of lymphocytes in infants causes the high plateau viral levels (102⁵ copies/ml) to be sustained.

Original language	English (US)
Pages (from-to)	1311-1313
Number of pages	3
Journal	AIDS
Volume	15
Issue number	10
DOIs	https://doi.org/10.1097/00002030-200107060-00015
State	Published - Jul 6 2001
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/00002030-200107060-00015

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AU - Biggar, R. J.

AU - Broadhead, R.

AU - Janes, M.

AU - Kumwenda, N.

AU - Taha, T. E.T.

AU - Cassol, S.

PY - 2001/7/6

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N2 - We examined weekly changes in viral levels in seven untreated infants infected with HIV at birth. Viral levels spiked immediately but reverted quickly to plateau levels typical of infant HIV infection within 2 weeks of first detected viraemia. We speculated that the depletion of naive, susceptible cells is responsible for the rapid decrease in spike levels and that the rapid replacement of lymphocytes in infants causes the high plateau viral levels (1025 copies/ml) to be sustained.

AB - We examined weekly changes in viral levels in seven untreated infants infected with HIV at birth. Viral levels spiked immediately but reverted quickly to plateau levels typical of infant HIV infection within 2 weeks of first detected viraemia. We speculated that the depletion of naive, susceptible cells is responsible for the rapid decrease in spike levels and that the rapid replacement of lymphocytes in infants causes the high plateau viral levels (1025 copies/ml) to be sustained.

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JO - AIDS

JF - AIDS

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ER -

Viral levels in newborn African infants undergoing primary HIV-1 infection

Abstract

ASJC Scopus subject areas

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