Viral infections and malformations of the nervous system.

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Experimental viral infections are described which cause malformations of the developing nervous system. These include influenza virus infection of chick embryos causing defects in neural tube closure and flexion, parvovirus infections of rodents and cats resulting in a granuloprival cerebellar malformation, and myxovirus infections of rodents inducing stenosis of the aqueduct of Sylvius. In each experimental model the pathogenesis of the malformation is different, but in each the resultant noninflammatory malformation bears resemblances to malformations in man considered to have a genetic basis.

Original languageEnglish (US)
Pages (from-to)56-63
Number of pages8
JournalBirth defects original article series
Issue number1
StatePublished - Feb 1 1971
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)


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