Viral infections and malformations of the nervous system.

Research output: Contribution to journalArticle

Abstract

Experimental viral infections are described which cause malformations of the developing nervous system. These include influenza virus infection of chick embryos causing defects in neural tube closure and flexion, parvovirus infections of rodents and cats resulting in a granuloprival cerebellar malformation, and myxovirus infections of rodents inducing stenosis of the aqueduct of Sylvius. In each experimental model the pathogenesis of the malformation is different, but in each the resultant noninflammatory malformation bears resemblances to malformations in man considered to have a genetic basis.

Original languageEnglish (US)
Pages (from-to)56-63
Number of pages8
JournalBirth Defects: Original Article Series
Volume7
Issue number1
StatePublished - Feb 1971
Externally publishedYes

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Nervous System Malformations
Virus Diseases
Orthomyxoviridae
Rodentia
Cerebral Aqueduct
Parvoviridae Infections
Neural Tube Defects
Chick Embryo
Pathologic Constriction
Cats
Theoretical Models
Infection

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)

Cite this

Viral infections and malformations of the nervous system. / Johnson, Richard.

In: Birth Defects: Original Article Series, Vol. 7, No. 1, 02.1971, p. 56-63.

Research output: Contribution to journalArticle

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