Viral Infections and Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey

Siobhan Sutcliffe, Sabine Rohrmann, Edward Giovannucci, Kenrad Edwin Nelson, Angelo Michael Demarzo, William B Isaacs, William G Nelson, Elizabeth A Platz

Research output: Contribution to journalArticle

Abstract

Purpose: Previous epidemiological studies described suggestive positive associations between sexually transmitted infections, particularly gonorrhea and human immunodeficiency virus infection, and lower urinary tract symptoms. To our knowledge no groups have investigated other infections, such as human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8, herpes simplex type 1, and hepatitis B and C virus infection, in relation to lower urinary tract symptoms. Therefore, we examined each of these associations in the Third National Health and Nutrition Examination Survey. Materials and Methods: The Third National Health and Nutrition Examination Survey is a representative, cross-sectional survey of the population in the United States that was done between 1988 and 1994. Each participant provided a blood sample and completed a computer assisted interview including questions on lower urinary tract symptoms (nocturia, incomplete emptying, hesitancy and weak stream). Blood samples were tested for IgG antibodies against each virus. Results: In younger men (ages 30 to 49 years) positive associations were observed between cytomegalovirus, human herpesvirus type 8, herpes simplex virus type 1, and hepatitis B and C virus antibody seropositivity, and lower urinary tract symptoms. In 50 to 59-year-old men positive associations were observed between human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8 and hepatitis C virus antibody seropositivity and lower urinary tract symptoms. In men 60 years or older only a slight, nonsignificant positive association was observed between cytomegalovirus antibody seropositivity and lower urinary tract symptoms. Conclusions: In this cross-sectional survey of American men suggestive positive associations were observed between several viral infections and lower urinary tract symptoms, primarily in 30 to 59-year-old men. These findings provide interesting hypotheses and preliminary evidence for future etiological studies of infections and lower urinary tract symptoms.

Original languageEnglish (US)
Pages (from-to)2181-2185
Number of pages5
JournalJournal of Urology
Volume178
Issue number5
DOIs
StatePublished - Nov 2007

Fingerprint

Lower Urinary Tract Symptoms
Nutrition Surveys
Virus Diseases
Cytomegalovirus
Human Herpesvirus 8
Hepatitis C Antibodies
Human Herpesvirus 2
Human papillomavirus 16
Cross-Sectional Studies
Nocturia
Hepatitis B Antibodies
Herpes Simplex
Antibodies
Gonorrhea
Human Herpesvirus 1
Sexually Transmitted Diseases
Infection
Hepatitis B virus
Hepacivirus
Epidemiologic Studies

Keywords

  • prostate
  • prostatic hyperplasia
  • prostatism
  • sexually transmitted diseases, viral
  • viral diseases

ASJC Scopus subject areas

  • Urology

Cite this

Viral Infections and Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey. / Sutcliffe, Siobhan; Rohrmann, Sabine; Giovannucci, Edward; Nelson, Kenrad Edwin; Demarzo, Angelo Michael; Isaacs, William B; Nelson, William G; Platz, Elizabeth A.

In: Journal of Urology, Vol. 178, No. 5, 11.2007, p. 2181-2185.

Research output: Contribution to journalArticle

@article{f12a256121494db883ada194f00e35e4,
title = "Viral Infections and Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey",
abstract = "Purpose: Previous epidemiological studies described suggestive positive associations between sexually transmitted infections, particularly gonorrhea and human immunodeficiency virus infection, and lower urinary tract symptoms. To our knowledge no groups have investigated other infections, such as human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8, herpes simplex type 1, and hepatitis B and C virus infection, in relation to lower urinary tract symptoms. Therefore, we examined each of these associations in the Third National Health and Nutrition Examination Survey. Materials and Methods: The Third National Health and Nutrition Examination Survey is a representative, cross-sectional survey of the population in the United States that was done between 1988 and 1994. Each participant provided a blood sample and completed a computer assisted interview including questions on lower urinary tract symptoms (nocturia, incomplete emptying, hesitancy and weak stream). Blood samples were tested for IgG antibodies against each virus. Results: In younger men (ages 30 to 49 years) positive associations were observed between cytomegalovirus, human herpesvirus type 8, herpes simplex virus type 1, and hepatitis B and C virus antibody seropositivity, and lower urinary tract symptoms. In 50 to 59-year-old men positive associations were observed between human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8 and hepatitis C virus antibody seropositivity and lower urinary tract symptoms. In men 60 years or older only a slight, nonsignificant positive association was observed between cytomegalovirus antibody seropositivity and lower urinary tract symptoms. Conclusions: In this cross-sectional survey of American men suggestive positive associations were observed between several viral infections and lower urinary tract symptoms, primarily in 30 to 59-year-old men. These findings provide interesting hypotheses and preliminary evidence for future etiological studies of infections and lower urinary tract symptoms.",
keywords = "prostate, prostatic hyperplasia, prostatism, sexually transmitted diseases, viral, viral diseases",
author = "Siobhan Sutcliffe and Sabine Rohrmann and Edward Giovannucci and Nelson, {Kenrad Edwin} and Demarzo, {Angelo Michael} and Isaacs, {William B} and Nelson, {William G} and Platz, {Elizabeth A}",
year = "2007",
month = "11",
doi = "10.1016/j.juro.2007.06.041",
language = "English (US)",
volume = "178",
pages = "2181--2185",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Viral Infections and Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey

AU - Sutcliffe, Siobhan

AU - Rohrmann, Sabine

AU - Giovannucci, Edward

AU - Nelson, Kenrad Edwin

AU - Demarzo, Angelo Michael

AU - Isaacs, William B

AU - Nelson, William G

AU - Platz, Elizabeth A

PY - 2007/11

Y1 - 2007/11

N2 - Purpose: Previous epidemiological studies described suggestive positive associations between sexually transmitted infections, particularly gonorrhea and human immunodeficiency virus infection, and lower urinary tract symptoms. To our knowledge no groups have investigated other infections, such as human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8, herpes simplex type 1, and hepatitis B and C virus infection, in relation to lower urinary tract symptoms. Therefore, we examined each of these associations in the Third National Health and Nutrition Examination Survey. Materials and Methods: The Third National Health and Nutrition Examination Survey is a representative, cross-sectional survey of the population in the United States that was done between 1988 and 1994. Each participant provided a blood sample and completed a computer assisted interview including questions on lower urinary tract symptoms (nocturia, incomplete emptying, hesitancy and weak stream). Blood samples were tested for IgG antibodies against each virus. Results: In younger men (ages 30 to 49 years) positive associations were observed between cytomegalovirus, human herpesvirus type 8, herpes simplex virus type 1, and hepatitis B and C virus antibody seropositivity, and lower urinary tract symptoms. In 50 to 59-year-old men positive associations were observed between human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8 and hepatitis C virus antibody seropositivity and lower urinary tract symptoms. In men 60 years or older only a slight, nonsignificant positive association was observed between cytomegalovirus antibody seropositivity and lower urinary tract symptoms. Conclusions: In this cross-sectional survey of American men suggestive positive associations were observed between several viral infections and lower urinary tract symptoms, primarily in 30 to 59-year-old men. These findings provide interesting hypotheses and preliminary evidence for future etiological studies of infections and lower urinary tract symptoms.

AB - Purpose: Previous epidemiological studies described suggestive positive associations between sexually transmitted infections, particularly gonorrhea and human immunodeficiency virus infection, and lower urinary tract symptoms. To our knowledge no groups have investigated other infections, such as human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8, herpes simplex type 1, and hepatitis B and C virus infection, in relation to lower urinary tract symptoms. Therefore, we examined each of these associations in the Third National Health and Nutrition Examination Survey. Materials and Methods: The Third National Health and Nutrition Examination Survey is a representative, cross-sectional survey of the population in the United States that was done between 1988 and 1994. Each participant provided a blood sample and completed a computer assisted interview including questions on lower urinary tract symptoms (nocturia, incomplete emptying, hesitancy and weak stream). Blood samples were tested for IgG antibodies against each virus. Results: In younger men (ages 30 to 49 years) positive associations were observed between cytomegalovirus, human herpesvirus type 8, herpes simplex virus type 1, and hepatitis B and C virus antibody seropositivity, and lower urinary tract symptoms. In 50 to 59-year-old men positive associations were observed between human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8 and hepatitis C virus antibody seropositivity and lower urinary tract symptoms. In men 60 years or older only a slight, nonsignificant positive association was observed between cytomegalovirus antibody seropositivity and lower urinary tract symptoms. Conclusions: In this cross-sectional survey of American men suggestive positive associations were observed between several viral infections and lower urinary tract symptoms, primarily in 30 to 59-year-old men. These findings provide interesting hypotheses and preliminary evidence for future etiological studies of infections and lower urinary tract symptoms.

KW - prostate

KW - prostatic hyperplasia

KW - prostatism

KW - sexually transmitted diseases, viral

KW - viral diseases

UR - http://www.scopus.com/inward/record.url?scp=35048899678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35048899678&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2007.06.041

DO - 10.1016/j.juro.2007.06.041

M3 - Article

C2 - 17870113

AN - SCOPUS:35048899678

VL - 178

SP - 2181

EP - 2185

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 5

ER -