Viral hijacking of G-protein-coupled-receptor signalling networks

Akrit Sodhi, Silvia Montaner, J. Silvia Gutkind

Research output: Contribution to journalReview articlepeer-review

Abstract

Viruses use a surprising diversity of approaches to hijack G-protein-coupled receptors and harness their activated intracellular signalling pathways. All of these approaches ultimately function to ensure viral replicative success and often contribute to their pathogenesis. Indeed, a single virus might deploy a repertoire of these strategies to regulate key intracellular survival, proliferative and chemotactic pathways. Understanding the contribution of these biochemical routes to viral pathogenesis might facilitate the development of effective target-specific therapeutic strategies against viral diseases.

Original languageEnglish (US)
Pages (from-to)998-1012
Number of pages15
JournalNature Reviews Molecular Cell Biology
Volume5
Issue number12
DOIs
StatePublished - Dec 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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