Viral Hepatitis in Health Care Personnel at The Johns Hopkins Hospital: The Seroprevalence of and Risk Factors for Hepatitis B Virus and Hepatitis C Virus Infection

David L Thomas, Stephanie H. Factor, Gabor D Kelen, Antonio S. Washington, Eric Taylor, Thomas C Quinn

Research output: Contribution to journalArticle


Background: Health care personnel are at increased risk of occupational acquisition of hepatitis B virus (HBV) infection. While effective vaccination for HBV is widely available, the prevalence of HBV and vaccine acceptance in hospital personnel have not been recently assessed. In addition, hepatitis C virus (HCV) is a newly recognized cause of parenterally acquired hepatitis, and the risk of HCV transmission to health care personnel remains unclear. Methods: From April to December 1991, health care personnel at The Johns Hopkins Hospital, Baltimore, Md, were offered anonymous testing for HBV and HCV and were asked to complete a confidential questionnaire. Serum samples were tested for HBV surface antigen and antibodies to HBV core antigen, HBV surface antigen, and HCV. Seroprevalence rates were compared with those detected in local blood donors during the same year. Results: Antibodies to HBV core antigen were found in 59 (6.2%) of 943 health care workers compared with 1879 (1.8%) of 104 239 local blood donors (P

Original languageEnglish (US)
Pages (from-to)1705-1712
Number of pages8
JournalArchives of Internal Medicine
Issue number14
Publication statusPublished - Jul 26 1993


ASJC Scopus subject areas

  • Internal Medicine

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