Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3

Alexander J. Thompson, Keyur Patel, Wan Long Chuang, Eric J. Lawitz, Maribel Rodriguez-Torres, Vinod K. Rustgi, Robert Flisiak, Stephen Pianko, Moises Diago, Sanjeev Arora, Graham R. Foster, Michael Torbenson, Yves Benhamou, David R. Nelson, Mark Sulkowski, Stefan Zeuzem, Erik Pulkstenis, G. Mani Subramanian, John G. McHutchison

Research output: Contribution to journalArticle

Abstract

Objectives: Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy. Methods: 2255 treatment-naive patients with chronic HCV genotype 1 or 2/3 were enrolled in two phase 3 trials of albinterferon alpha-2b versus pegylated interferon alpha-2a for 48 or 24 weeks, respectively. IR was measured before treatment and 12 weeks after treatment using homeostasis model assessment (HOMA)-IR. Results: Paired HOMA-IR measurements were available in 1038 non-diabetic patients (497 with genotype 1; 541 with genotype 2/3). At baseline the prevalence of HOMA-IR >3 was greater in patients with genotype 1 than 2/3 (33% vs 27%; p=0.048). There was a significant reduction in the prevalence of IR in patients with genotype 1 achieving SVR (δ 10%; p

Original languageEnglish (US)
Pages (from-to)128-134
Number of pages7
JournalGut
Volume61
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Chronic Hepatitis C
Insulin Resistance
Genotype
Hepacivirus
Homeostasis
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Thompson, A. J., Patel, K., Chuang, W. L., Lawitz, E. J., Rodriguez-Torres, M., Rustgi, V. K., ... McHutchison, J. G. (2012). Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3. Gut, 61(1), 128-134. https://doi.org/10.1136/gut.2010.236158

Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3. / Thompson, Alexander J.; Patel, Keyur; Chuang, Wan Long; Lawitz, Eric J.; Rodriguez-Torres, Maribel; Rustgi, Vinod K.; Flisiak, Robert; Pianko, Stephen; Diago, Moises; Arora, Sanjeev; Foster, Graham R.; Torbenson, Michael; Benhamou, Yves; Nelson, David R.; Sulkowski, Mark; Zeuzem, Stefan; Pulkstenis, Erik; Subramanian, G. Mani; McHutchison, John G.

In: Gut, Vol. 61, No. 1, 01.2012, p. 128-134.

Research output: Contribution to journalArticle

Thompson, AJ, Patel, K, Chuang, WL, Lawitz, EJ, Rodriguez-Torres, M, Rustgi, VK, Flisiak, R, Pianko, S, Diago, M, Arora, S, Foster, GR, Torbenson, M, Benhamou, Y, Nelson, DR, Sulkowski, M, Zeuzem, S, Pulkstenis, E, Subramanian, GM & McHutchison, JG 2012, 'Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3', Gut, vol. 61, no. 1, pp. 128-134. https://doi.org/10.1136/gut.2010.236158
Thompson AJ, Patel K, Chuang WL, Lawitz EJ, Rodriguez-Torres M, Rustgi VK et al. Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3. Gut. 2012 Jan;61(1):128-134. https://doi.org/10.1136/gut.2010.236158
Thompson, Alexander J. ; Patel, Keyur ; Chuang, Wan Long ; Lawitz, Eric J. ; Rodriguez-Torres, Maribel ; Rustgi, Vinod K. ; Flisiak, Robert ; Pianko, Stephen ; Diago, Moises ; Arora, Sanjeev ; Foster, Graham R. ; Torbenson, Michael ; Benhamou, Yves ; Nelson, David R. ; Sulkowski, Mark ; Zeuzem, Stefan ; Pulkstenis, Erik ; Subramanian, G. Mani ; McHutchison, John G. / Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3. In: Gut. 2012 ; Vol. 61, No. 1. pp. 128-134.
@article{416e4691183d41ff8f5a2add67b66254,
title = "Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3",
abstract = "Objectives: Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy. Methods: 2255 treatment-naive patients with chronic HCV genotype 1 or 2/3 were enrolled in two phase 3 trials of albinterferon alpha-2b versus pegylated interferon alpha-2a for 48 or 24 weeks, respectively. IR was measured before treatment and 12 weeks after treatment using homeostasis model assessment (HOMA)-IR. Results: Paired HOMA-IR measurements were available in 1038 non-diabetic patients (497 with genotype 1; 541 with genotype 2/3). At baseline the prevalence of HOMA-IR >3 was greater in patients with genotype 1 than 2/3 (33{\%} vs 27{\%}; p=0.048). There was a significant reduction in the prevalence of IR in patients with genotype 1 achieving SVR (δ 10{\%}; p",
author = "Thompson, {Alexander J.} and Keyur Patel and Chuang, {Wan Long} and Lawitz, {Eric J.} and Maribel Rodriguez-Torres and Rustgi, {Vinod K.} and Robert Flisiak and Stephen Pianko and Moises Diago and Sanjeev Arora and Foster, {Graham R.} and Michael Torbenson and Yves Benhamou and Nelson, {David R.} and Mark Sulkowski and Stefan Zeuzem and Erik Pulkstenis and Subramanian, {G. Mani} and McHutchison, {John G.}",
year = "2012",
month = "1",
doi = "10.1136/gut.2010.236158",
language = "English (US)",
volume = "61",
pages = "128--134",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ Publishing Group",
number = "1",

}

TY - JOUR

T1 - Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3

AU - Thompson, Alexander J.

AU - Patel, Keyur

AU - Chuang, Wan Long

AU - Lawitz, Eric J.

AU - Rodriguez-Torres, Maribel

AU - Rustgi, Vinod K.

AU - Flisiak, Robert

AU - Pianko, Stephen

AU - Diago, Moises

AU - Arora, Sanjeev

AU - Foster, Graham R.

AU - Torbenson, Michael

AU - Benhamou, Yves

AU - Nelson, David R.

AU - Sulkowski, Mark

AU - Zeuzem, Stefan

AU - Pulkstenis, Erik

AU - Subramanian, G. Mani

AU - McHutchison, John G.

PY - 2012/1

Y1 - 2012/1

N2 - Objectives: Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy. Methods: 2255 treatment-naive patients with chronic HCV genotype 1 or 2/3 were enrolled in two phase 3 trials of albinterferon alpha-2b versus pegylated interferon alpha-2a for 48 or 24 weeks, respectively. IR was measured before treatment and 12 weeks after treatment using homeostasis model assessment (HOMA)-IR. Results: Paired HOMA-IR measurements were available in 1038 non-diabetic patients (497 with genotype 1; 541 with genotype 2/3). At baseline the prevalence of HOMA-IR >3 was greater in patients with genotype 1 than 2/3 (33% vs 27%; p=0.048). There was a significant reduction in the prevalence of IR in patients with genotype 1 achieving SVR (δ 10%; p

AB - Objectives: Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy. Methods: 2255 treatment-naive patients with chronic HCV genotype 1 or 2/3 were enrolled in two phase 3 trials of albinterferon alpha-2b versus pegylated interferon alpha-2a for 48 or 24 weeks, respectively. IR was measured before treatment and 12 weeks after treatment using homeostasis model assessment (HOMA)-IR. Results: Paired HOMA-IR measurements were available in 1038 non-diabetic patients (497 with genotype 1; 541 with genotype 2/3). At baseline the prevalence of HOMA-IR >3 was greater in patients with genotype 1 than 2/3 (33% vs 27%; p=0.048). There was a significant reduction in the prevalence of IR in patients with genotype 1 achieving SVR (δ 10%; p

UR - http://www.scopus.com/inward/record.url?scp=83555177345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83555177345&partnerID=8YFLogxK

U2 - 10.1136/gut.2010.236158

DO - 10.1136/gut.2010.236158

M3 - Article

VL - 61

SP - 128

EP - 134

JO - Gut

JF - Gut

SN - 0017-5749

IS - 1

ER -