Vi SEROLOGY IN DETECTION OF CHRONIC SALMONELLA TYPHI CARRIERS IN AN ENDEMIC AREA

Claudio F. Lanata, Conrado Ristori, Luis Jimenez, Julio Garcia, Myron M. Levine, Robert E. Black, Mario Salcedo, Viviana Sotomayor

Research output: Contribution to journalArticle

Abstract

A passive haemagglutination assay measuring antibody to highly purified Vi antigen, known to be sensitive and specific for the detection of chronic Salmonella typhi carriers in a non-endemic area, was assessed in an endemic area. A reciprocal serum Vi antibody titre of 160 was found to have a sensitivity of 75%, specificity of 92%, and a high predictive value in screening for chronic S typhi carriers in high-risk population groups (eg, women over 40 years). This simple assay can screen for chronic S typhi carriers even in areas where typhoid fever is highly endemic.

Original languageEnglish (US)
Pages (from-to)441-443
Number of pages3
JournalThe Lancet
Volume322
Issue number8347
DOIs
StatePublished - Aug 20 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Lanata, C. F., Ristori, C., Jimenez, L., Garcia, J., Levine, M. M., Black, R. E., Salcedo, M., & Sotomayor, V. (1983). Vi SEROLOGY IN DETECTION OF CHRONIC SALMONELLA TYPHI CARRIERS IN AN ENDEMIC AREA. The Lancet, 322(8347), 441-443. https://doi.org/10.1016/S0140-6736(83)90401-4