Veterans have greater variability in their perception of binocular alignment

Michael C Schubert, Yoav Gimmon, Jennifer Millar, Kelly J. Brewer, Dale Roberts, Mark J Shelhamer, Charles A Rohde, Jorge M. Serrador

Research output: Contribution to journalArticle

Abstract

Introduction A significant population of our wounded veterans suffer long-term functional consequences of visual deficit, disorientation, dizziness, and an impaired ability to read. These symptoms may be related to damage within the otolith pathways that contribute to ocular alignment. The purpose of this study was to compare perception of vertical and torsional ocular alignment between veterans and healthy controls in an upright and supine test position. Materials and methods Veterans (n = 26) with reports of dizziness were recruited from the East Orange Veterans Administration Hospital. Healthy controls (n = 26) were recruited from both Johns Hopkins University and the East Orange VA. Each subject performed 20 trials each of a novel vertical and torsional binocular alignment perception test. Veterans underwent semicircular canal and otolith pathway function testing. Results 88% of the Veterans had an absent otolith response. Only the veterans had an abnormally large variability in perception of both vertical and torsional ocular alignment, and in both upright and supine position. Neither post-traumatic stress disorder, nor depression contributed to the misperception in binocular alignment. Conclusions Our novel method of measuring vertical and torsional misalignment distinguishes veterans with dizziness from healthy controls. The high prevalence of absent otolith function seems to explain this result. Further studies are needed to better understand the fundamental mechanism responsible for the increased variability of perception of binocular alignment.

Original languageEnglish (US)
Article numbere0209622
JournalPLoS One
Volume13
Issue number12
DOIs
StatePublished - Dec 1 2018

Fingerprint

veterans
Binoculars
Veterans
Otolithic Membrane
otoliths
Dizziness
Supine Position
eyes
Veterans Hospitals
Semicircular Canals
Confusion
Canals
United States Department of Veterans Affairs
Aptitude
Post-Traumatic Stress Disorders
testing
Depression
Testing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Veterans have greater variability in their perception of binocular alignment. / Schubert, Michael C; Gimmon, Yoav; Millar, Jennifer; Brewer, Kelly J.; Roberts, Dale; Shelhamer, Mark J; Rohde, Charles A; Serrador, Jorge M.

In: PLoS One, Vol. 13, No. 12, e0209622, 01.12.2018.

Research output: Contribution to journalArticle

Schubert, Michael C ; Gimmon, Yoav ; Millar, Jennifer ; Brewer, Kelly J. ; Roberts, Dale ; Shelhamer, Mark J ; Rohde, Charles A ; Serrador, Jorge M. / Veterans have greater variability in their perception of binocular alignment. In: PLoS One. 2018 ; Vol. 13, No. 12.
@article{4c11384a89d44458af6107f6f525b742,
title = "Veterans have greater variability in their perception of binocular alignment",
abstract = "Introduction A significant population of our wounded veterans suffer long-term functional consequences of visual deficit, disorientation, dizziness, and an impaired ability to read. These symptoms may be related to damage within the otolith pathways that contribute to ocular alignment. The purpose of this study was to compare perception of vertical and torsional ocular alignment between veterans and healthy controls in an upright and supine test position. Materials and methods Veterans (n = 26) with reports of dizziness were recruited from the East Orange Veterans Administration Hospital. Healthy controls (n = 26) were recruited from both Johns Hopkins University and the East Orange VA. Each subject performed 20 trials each of a novel vertical and torsional binocular alignment perception test. Veterans underwent semicircular canal and otolith pathway function testing. Results 88{\%} of the Veterans had an absent otolith response. Only the veterans had an abnormally large variability in perception of both vertical and torsional ocular alignment, and in both upright and supine position. Neither post-traumatic stress disorder, nor depression contributed to the misperception in binocular alignment. Conclusions Our novel method of measuring vertical and torsional misalignment distinguishes veterans with dizziness from healthy controls. The high prevalence of absent otolith function seems to explain this result. Further studies are needed to better understand the fundamental mechanism responsible for the increased variability of perception of binocular alignment.",
author = "Schubert, {Michael C} and Yoav Gimmon and Jennifer Millar and Brewer, {Kelly J.} and Dale Roberts and Shelhamer, {Mark J} and Rohde, {Charles A} and Serrador, {Jorge M.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1371/journal.pone.0209622",
language = "English (US)",
volume = "13",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

TY - JOUR

T1 - Veterans have greater variability in their perception of binocular alignment

AU - Schubert, Michael C

AU - Gimmon, Yoav

AU - Millar, Jennifer

AU - Brewer, Kelly J.

AU - Roberts, Dale

AU - Shelhamer, Mark J

AU - Rohde, Charles A

AU - Serrador, Jorge M.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Introduction A significant population of our wounded veterans suffer long-term functional consequences of visual deficit, disorientation, dizziness, and an impaired ability to read. These symptoms may be related to damage within the otolith pathways that contribute to ocular alignment. The purpose of this study was to compare perception of vertical and torsional ocular alignment between veterans and healthy controls in an upright and supine test position. Materials and methods Veterans (n = 26) with reports of dizziness were recruited from the East Orange Veterans Administration Hospital. Healthy controls (n = 26) were recruited from both Johns Hopkins University and the East Orange VA. Each subject performed 20 trials each of a novel vertical and torsional binocular alignment perception test. Veterans underwent semicircular canal and otolith pathway function testing. Results 88% of the Veterans had an absent otolith response. Only the veterans had an abnormally large variability in perception of both vertical and torsional ocular alignment, and in both upright and supine position. Neither post-traumatic stress disorder, nor depression contributed to the misperception in binocular alignment. Conclusions Our novel method of measuring vertical and torsional misalignment distinguishes veterans with dizziness from healthy controls. The high prevalence of absent otolith function seems to explain this result. Further studies are needed to better understand the fundamental mechanism responsible for the increased variability of perception of binocular alignment.

AB - Introduction A significant population of our wounded veterans suffer long-term functional consequences of visual deficit, disorientation, dizziness, and an impaired ability to read. These symptoms may be related to damage within the otolith pathways that contribute to ocular alignment. The purpose of this study was to compare perception of vertical and torsional ocular alignment between veterans and healthy controls in an upright and supine test position. Materials and methods Veterans (n = 26) with reports of dizziness were recruited from the East Orange Veterans Administration Hospital. Healthy controls (n = 26) were recruited from both Johns Hopkins University and the East Orange VA. Each subject performed 20 trials each of a novel vertical and torsional binocular alignment perception test. Veterans underwent semicircular canal and otolith pathway function testing. Results 88% of the Veterans had an absent otolith response. Only the veterans had an abnormally large variability in perception of both vertical and torsional ocular alignment, and in both upright and supine position. Neither post-traumatic stress disorder, nor depression contributed to the misperception in binocular alignment. Conclusions Our novel method of measuring vertical and torsional misalignment distinguishes veterans with dizziness from healthy controls. The high prevalence of absent otolith function seems to explain this result. Further studies are needed to better understand the fundamental mechanism responsible for the increased variability of perception of binocular alignment.

UR - http://www.scopus.com/inward/record.url?scp=85059222819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059222819&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0209622

DO - 10.1371/journal.pone.0209622

M3 - Article

C2 - 30586453

AN - SCOPUS:85059222819

VL - 13

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e0209622

ER -