Vessel-specific quantification of neonatal cerebral venous oxygenation

Dengrong Jiang, Hanzhang Lu, Charlamaine Parkinson, Pan Su, Zhiliang Wei, Li Pan, Aylin Tekes, Thierry A.G.M. Huisman, W. Christopher Golden, Peiying Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Noninvasive measurement of cerebral venous oxygenation (Yv) in neonates is important in the assessment of brain oxygen extraction and consumption, and may be useful in characterizing brain development and neonatal brain diseases. This study aims to develop a rapid method for vessel-specific measurement of Yv in neonates. Methods: We developed a pulse sequence, named accelerated T2-relaxation-under-phase-contrast (aTRUPC), which consists of velocity-encoding phase-contrast module to isolate pure blood signal, flow-insensitive T2-preparation to quantify blood T2, and turbo-field-echo (TFE) scheme for rapid image acquisition, which is critical for neonatal MRI. A series of studies were conducted. First, the pulse sequence was optimized in terms of TFE factor, velocity encoding (VENC), and slice thickness for best sensitivity. Second, to account for the influence of TFE acquisition on T2 quantification, simulation and experiments were conducted to establish the relationship between TFE-T2 and standard T2. Finally, the complete aTRUPC sequence was applied on a group of healthy neonates and normative Yv values were determined. Results: Optimal parameters of aTRUPC in neonates were found to be a TFE factor of 15, VENC of 5 cm/s, and slice thickness of 10 mm. The TFE-T2 was on average 3.9% lower than standard T2. These two measures were strongly correlated (R2= 0.86); thus their difference can be accounted for by a correction equation, T2,standard = 1.2002 × T2,TFE− 10.6276. Neonatal Yv values in veins draining cortical brain and those draining central brain were 64.8 ± 2.9% and 70.2 ± 3.3%, respectively, with a significant difference (P =.02). Conclusion: The aTRUPC MRI has the potential to provide vessel-specific quantification of cerebral Yv in neonates.

Original languageEnglish (US)
Pages (from-to)1129-1139
Number of pages11
JournalMagnetic resonance in medicine
Volume82
Issue number3
DOIs
StatePublished - Sep 2019

Keywords

  • T-relaxation-under-spin-tagging (TRUST)
  • aTRUPC
  • cerebral venous oxygenation
  • deep venous system
  • neonates
  • oxygen consumption

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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