TY - JOUR
T1 - Vessel-specific quantification of neonatal cerebral venous oxygenation
AU - Jiang, Dengrong
AU - Lu, Hanzhang
AU - Parkinson, Charlamaine
AU - Su, Pan
AU - Wei, Zhiliang
AU - Pan, Li
AU - Tekes, Aylin
AU - Huisman, Thierry A.G.M.
AU - Golden, W. Christopher
AU - Liu, Peiying
N1 - Funding Information:
Grant Sponsors: NIH R01 NS109029, R01 NS106702, R01 NS106711, R01 MH084021, R21NS100006, R21 NS095342, P41 EB015909.
Publisher Copyright:
© 2019 International Society for Magnetic Resonance in Medicine
PY - 2019/9
Y1 - 2019/9
N2 - Purpose: Noninvasive measurement of cerebral venous oxygenation (Yv) in neonates is important in the assessment of brain oxygen extraction and consumption, and may be useful in characterizing brain development and neonatal brain diseases. This study aims to develop a rapid method for vessel-specific measurement of Yv in neonates. Methods: We developed a pulse sequence, named accelerated T2-relaxation-under-phase-contrast (aTRUPC), which consists of velocity-encoding phase-contrast module to isolate pure blood signal, flow-insensitive T2-preparation to quantify blood T2, and turbo-field-echo (TFE) scheme for rapid image acquisition, which is critical for neonatal MRI. A series of studies were conducted. First, the pulse sequence was optimized in terms of TFE factor, velocity encoding (VENC), and slice thickness for best sensitivity. Second, to account for the influence of TFE acquisition on T2 quantification, simulation and experiments were conducted to establish the relationship between TFE-T2 and standard T2. Finally, the complete aTRUPC sequence was applied on a group of healthy neonates and normative Yv values were determined. Results: Optimal parameters of aTRUPC in neonates were found to be a TFE factor of 15, VENC of 5 cm/s, and slice thickness of 10 mm. The TFE-T2 was on average 3.9% lower than standard T2. These two measures were strongly correlated (R2= 0.86); thus their difference can be accounted for by a correction equation, T2,standard = 1.2002 × T2,TFE− 10.6276. Neonatal Yv values in veins draining cortical brain and those draining central brain were 64.8 ± 2.9% and 70.2 ± 3.3%, respectively, with a significant difference (P =.02). Conclusion: The aTRUPC MRI has the potential to provide vessel-specific quantification of cerebral Yv in neonates.
AB - Purpose: Noninvasive measurement of cerebral venous oxygenation (Yv) in neonates is important in the assessment of brain oxygen extraction and consumption, and may be useful in characterizing brain development and neonatal brain diseases. This study aims to develop a rapid method for vessel-specific measurement of Yv in neonates. Methods: We developed a pulse sequence, named accelerated T2-relaxation-under-phase-contrast (aTRUPC), which consists of velocity-encoding phase-contrast module to isolate pure blood signal, flow-insensitive T2-preparation to quantify blood T2, and turbo-field-echo (TFE) scheme for rapid image acquisition, which is critical for neonatal MRI. A series of studies were conducted. First, the pulse sequence was optimized in terms of TFE factor, velocity encoding (VENC), and slice thickness for best sensitivity. Second, to account for the influence of TFE acquisition on T2 quantification, simulation and experiments were conducted to establish the relationship between TFE-T2 and standard T2. Finally, the complete aTRUPC sequence was applied on a group of healthy neonates and normative Yv values were determined. Results: Optimal parameters of aTRUPC in neonates were found to be a TFE factor of 15, VENC of 5 cm/s, and slice thickness of 10 mm. The TFE-T2 was on average 3.9% lower than standard T2. These two measures were strongly correlated (R2= 0.86); thus their difference can be accounted for by a correction equation, T2,standard = 1.2002 × T2,TFE− 10.6276. Neonatal Yv values in veins draining cortical brain and those draining central brain were 64.8 ± 2.9% and 70.2 ± 3.3%, respectively, with a significant difference (P =.02). Conclusion: The aTRUPC MRI has the potential to provide vessel-specific quantification of cerebral Yv in neonates.
KW - T-relaxation-under-spin-tagging (TRUST)
KW - aTRUPC
KW - cerebral venous oxygenation
KW - deep venous system
KW - neonates
KW - oxygen consumption
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U2 - 10.1002/mrm.27788
DO - 10.1002/mrm.27788
M3 - Article
C2 - 31066104
AN - SCOPUS:85065505765
VL - 82
SP - 1129
EP - 1139
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 3
ER -