Vesicular pemphigoid in a 16-year-old boy

Adam S. Geyer, Detlef Zillikens, Christian Skrobek, Bernard Cohen, Grant J. Anhalt, Hossein C. Nousari

Research output: Contribution to journalArticle

Abstract

We describe a case of a 16-year-old African-American boy with bullous pemphigoid (BP), an acquired autoimmune blistering disease that is rarely seen in children. The patient's lesions, however, were distinctly herpetiform, complicating initial diagnosis and therapy. A diagnosis of BP was made by direct and indirect immunofluorescence. Immunoblotting and enzyme-linked immunosorbent assay analysis confirmed the presence of autoantibodies directed against the BP180 antigen. The autoantibodies reacted with the same epitopes within the immunodominant BP180 NC16A domain that have previously been shown to be the target of autoantibodies in BP. This case describes an uncommon disease in the pediatric population and should be included in the differential diagnosis in young patients with an unusual generalized vesicular eruption.

Original languageEnglish (US)
Pages (from-to)722-724
Number of pages3
JournalJournal of the American Academy of Dermatology
Volume49
Issue number4
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Dermatology

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