Very long-chain fatty acids in diagnosis, pathogenesis, and therapy of peroxisomal disorders

Hugo W. Moser, Ann B. Moser

Research output: Contribution to journalArticle

Abstract

Abnormally high levels of very long-chain fatty acids (VLCFA) are a feature in nine of the fifteen peroxisomal disorders that have been identified so far. Saturated VLCFA accumulate in X-linked adrenoleukodystrophy, appear to disrupt membrane structure, and may play a role in the pathogenesis of a brain inflammatory response. Dietary therapy initiated when patients are still asymptomatic may be of clinical benefit.

Original languageEnglish (US)
Pages (from-to)S-141-S-145
JournalLipids
Volume31
Issue number3 SUPPL.
StatePublished - Mar 1 1996

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

Cite this