Verumontanum mucosal gland hyperplasia in prostatic needle biopsy specimens: A mimic of low grade prostatic adenocarcinoma

P. B. Gaudin, T. M. Wheeler, J. I. Epstein

Research output: Contribution to journalArticle

Abstract

The histologic features of five cases of verumontanum mucosal gland hyperplasia (VMGH) in prostatic needle biopsy specimens are re ported. All cases were initially reviewed in consultation by one of two of the authors (JIE or TMW) and in all cases, the submitted differential diagnosis included low grade adenocarcinoma. In all cases, VMGH was characterized by a relatively cell-circumscribed collection of closely packed glands, and was typically observed immediately subjacent to urothelium. A basal cell layer was readily identifiable in routine hematoxylin-and-eosin stained sections. The luminal contents of the verumontanum mucosal glands were distinctive and consisted of lamellated eosinophilic concretions typical of corpora amylacea, as well as unique orange-red concretions that were commonly fragmented. The histologic features of VMGH are characteristic and allow distinction from other small glandular proliferations of the prostate including nephrogenic adenoma, adenosis (atypical adenomatous hyperplasia), and low grade adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)620-626
Number of pages7
JournalAmerican journal of clinical pathology
Volume104
Issue number6
DOIs
StatePublished - Jan 1 1995

Keywords

  • Adenocarcinoma
  • Adenosis
  • Concretions
  • Corpora amylacea
  • Hyperplasia
  • Needle biopsy
  • Prostate
  • Verumontanum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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