TY - JOUR
T1 - Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3
AU - Platz, Elizabeth A.
AU - Pollak, Michael N.
AU - Willett, Walter C.
AU - Giovannucci, Edward
N1 - Funding Information:
Supported by research grants CA 55075 and HL 35464 from the National Institutes of Health, Department of Health and Human Services.
PY - 2000/6
Y1 - 2000/6
N2 - Background: A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protien, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined. Objective: We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in middle-aged and elderly men. Methods: Participants were 431 male members of the Health Professionals Follow-up Study who responded to a question in 1992 on their hair pattern at 45 years of age and who were 47 to 81 years old when they provided a blood specimen in 1993-1994. Odds ratios (ORs) of vertex balding associated with IGF-1 and IGFBP-3 were estimated from logistic regression models mutually adjusting for each other and controlling for age at blood draw. Results: Of the 431 men, 128 had vertex balding at age 45. Compared with men who were not balding, for a 1 standard deviation increase in plasma IGF-1 level (72.4 ng/mL), the OR for vertex balding was 1.31 (95% CI, 0.95-1.81). For a 1 standard deviation increase in plasma IGFBP-3-(957-ng/mL), the OR for vertex balding was 0.62 (95% CI, 0.44-0.88) Conclusion: Older men with vertex balding have lower circulating levels of IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.
AB - Background: A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protien, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined. Objective: We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in middle-aged and elderly men. Methods: Participants were 431 male members of the Health Professionals Follow-up Study who responded to a question in 1992 on their hair pattern at 45 years of age and who were 47 to 81 years old when they provided a blood specimen in 1993-1994. Odds ratios (ORs) of vertex balding associated with IGF-1 and IGFBP-3 were estimated from logistic regression models mutually adjusting for each other and controlling for age at blood draw. Results: Of the 431 men, 128 had vertex balding at age 45. Compared with men who were not balding, for a 1 standard deviation increase in plasma IGF-1 level (72.4 ng/mL), the OR for vertex balding was 1.31 (95% CI, 0.95-1.81). For a 1 standard deviation increase in plasma IGFBP-3-(957-ng/mL), the OR for vertex balding was 0.62 (95% CI, 0.44-0.88) Conclusion: Older men with vertex balding have lower circulating levels of IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.
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U2 - 10.1067/mjd.2000.103987
DO - 10.1067/mjd.2000.103987
M3 - Article
C2 - 10827403
AN - SCOPUS:0034120183
SN - 0190-9622
VL - 42
SP - 1003
EP - 1007
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -