Abstract
Quantitative computed tomography of the lumbar spine was carried out in 28 patients with osteogenesis imperfecta (OI) in order to measure vertebral trabecular bone mineral concentration (BMC). The patients ranged in age from 6-73 years, and included 3 of the 4 major clinical subtypes of the disease. The findings underscore the heterogeneity of osteogenesis imperfecta even among family members with the same disease type. In addition, cross-sectional analysis of Type I OI patients suggests that BMC during young adulthood averages about 70% of normal, and subsequently falls more rapidly than in normal patients. BMC tends to be lower in the more severe forms of OI. Decreased BMC was not found in a few otherwise normal relatives with scoliosis or joint laxity.
Original language | English (US) |
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Pages (from-to) | 14-18 |
Number of pages | 5 |
Journal | Calcified Tissue International |
Volume | 37 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1985 |
Externally published | Yes |
Keywords
- Bone densitometry
- Computed tomography
- Osteogenesis imperfecta
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Orthopedics and Sports Medicine
- Endocrinology