Vertebral bone mineral content in osteogenesis imperfecta

David Kurtz, Kathleen Morrish, Jay Shapiro

Research output: Contribution to journalArticlepeer-review

Abstract

Quantitative computed tomography of the lumbar spine was carried out in 28 patients with osteogenesis imperfecta (OI) in order to measure vertebral trabecular bone mineral concentration (BMC). The patients ranged in age from 6-73 years, and included 3 of the 4 major clinical subtypes of the disease. The findings underscore the heterogeneity of osteogenesis imperfecta even among family members with the same disease type. In addition, cross-sectional analysis of Type I OI patients suggests that BMC during young adulthood averages about 70% of normal, and subsequently falls more rapidly than in normal patients. BMC tends to be lower in the more severe forms of OI. Decreased BMC was not found in a few otherwise normal relatives with scoliosis or joint laxity.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalCalcified Tissue International
Volume37
Issue number1
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Keywords

  • Bone densitometry
  • Computed tomography
  • Osteogenesis imperfecta

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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