Vergence-dependent adaptation of the vestibulo-ocular reflex

Richard F. Lewis, Richard A. Clendaniel, David Samuel Zee

Research output: Contribution to journalArticle

Abstract

The gain of the vestibulo-ocular reflex (VOR) normally depends on the distance between the subject and the visual target, but it remains uncertain whether vergence angle can be linked to changes in VOR gain through a process of context-dependent adaptation. In this study, we examined this question with an adaptation paradigm that modified the normal relationship between vergence angle and retinal image motion. Subjects were rotated sinusoidally while they viewed an optokinetic (OKN) stimulus through either diverging or converging prisms. In three subjects the diverging prisms were worn while the OKN stimulus moved out of phase with the head, and the converging prisms were worn when the OKN stimulus moved in-phase with the head. The relationship between the vergence angle and OKN stimulus was reversed in the fourth subject. After 2 h of training, the VOR gain at the two vergence angles changed significantly in all of the subjects, evidenced by the two different VOR gains that could be immediately accessed by switching between the diverged and converged conditions. The results demonstrate that subjects can learn to use vergence angle as the contextual cue that retrieves adaptive changes in the angular VOR.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalExperimental Brain Research
Volume152
Issue number3
DOIs
StatePublished - Oct 2003

Fingerprint

Vestibulo-Ocular Reflex
Head
Cues

Keywords

  • Adaptation
  • Context
  • Human
  • Vergence
  • Vestibular

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vergence-dependent adaptation of the vestibulo-ocular reflex. / Lewis, Richard F.; Clendaniel, Richard A.; Zee, David Samuel.

In: Experimental Brain Research, Vol. 152, No. 3, 10.2003, p. 335-340.

Research output: Contribution to journalArticle

Lewis, Richard F. ; Clendaniel, Richard A. ; Zee, David Samuel. / Vergence-dependent adaptation of the vestibulo-ocular reflex. In: Experimental Brain Research. 2003 ; Vol. 152, No. 3. pp. 335-340.
@article{fa2faa26083c45a7a50ded0643b53238,
title = "Vergence-dependent adaptation of the vestibulo-ocular reflex",
abstract = "The gain of the vestibulo-ocular reflex (VOR) normally depends on the distance between the subject and the visual target, but it remains uncertain whether vergence angle can be linked to changes in VOR gain through a process of context-dependent adaptation. In this study, we examined this question with an adaptation paradigm that modified the normal relationship between vergence angle and retinal image motion. Subjects were rotated sinusoidally while they viewed an optokinetic (OKN) stimulus through either diverging or converging prisms. In three subjects the diverging prisms were worn while the OKN stimulus moved out of phase with the head, and the converging prisms were worn when the OKN stimulus moved in-phase with the head. The relationship between the vergence angle and OKN stimulus was reversed in the fourth subject. After 2 h of training, the VOR gain at the two vergence angles changed significantly in all of the subjects, evidenced by the two different VOR gains that could be immediately accessed by switching between the diverged and converged conditions. The results demonstrate that subjects can learn to use vergence angle as the contextual cue that retrieves adaptive changes in the angular VOR.",
keywords = "Adaptation, Context, Human, Vergence, Vestibular",
author = "Lewis, {Richard F.} and Clendaniel, {Richard A.} and Zee, {David Samuel}",
year = "2003",
month = "10",
doi = "10.1007/s00221-003-1563-9",
language = "English (US)",
volume = "152",
pages = "335--340",
journal = "Experimental Brain Research",
issn = "0014-4819",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Vergence-dependent adaptation of the vestibulo-ocular reflex

AU - Lewis, Richard F.

AU - Clendaniel, Richard A.

AU - Zee, David Samuel

PY - 2003/10

Y1 - 2003/10

N2 - The gain of the vestibulo-ocular reflex (VOR) normally depends on the distance between the subject and the visual target, but it remains uncertain whether vergence angle can be linked to changes in VOR gain through a process of context-dependent adaptation. In this study, we examined this question with an adaptation paradigm that modified the normal relationship between vergence angle and retinal image motion. Subjects were rotated sinusoidally while they viewed an optokinetic (OKN) stimulus through either diverging or converging prisms. In three subjects the diverging prisms were worn while the OKN stimulus moved out of phase with the head, and the converging prisms were worn when the OKN stimulus moved in-phase with the head. The relationship between the vergence angle and OKN stimulus was reversed in the fourth subject. After 2 h of training, the VOR gain at the two vergence angles changed significantly in all of the subjects, evidenced by the two different VOR gains that could be immediately accessed by switching between the diverged and converged conditions. The results demonstrate that subjects can learn to use vergence angle as the contextual cue that retrieves adaptive changes in the angular VOR.

AB - The gain of the vestibulo-ocular reflex (VOR) normally depends on the distance between the subject and the visual target, but it remains uncertain whether vergence angle can be linked to changes in VOR gain through a process of context-dependent adaptation. In this study, we examined this question with an adaptation paradigm that modified the normal relationship between vergence angle and retinal image motion. Subjects were rotated sinusoidally while they viewed an optokinetic (OKN) stimulus through either diverging or converging prisms. In three subjects the diverging prisms were worn while the OKN stimulus moved out of phase with the head, and the converging prisms were worn when the OKN stimulus moved in-phase with the head. The relationship between the vergence angle and OKN stimulus was reversed in the fourth subject. After 2 h of training, the VOR gain at the two vergence angles changed significantly in all of the subjects, evidenced by the two different VOR gains that could be immediately accessed by switching between the diverged and converged conditions. The results demonstrate that subjects can learn to use vergence angle as the contextual cue that retrieves adaptive changes in the angular VOR.

KW - Adaptation

KW - Context

KW - Human

KW - Vergence

KW - Vestibular

UR - http://www.scopus.com/inward/record.url?scp=0141452033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141452033&partnerID=8YFLogxK

U2 - 10.1007/s00221-003-1563-9

DO - 10.1007/s00221-003-1563-9

M3 - Article

C2 - 12879175

AN - SCOPUS:0141452033

VL - 152

SP - 335

EP - 340

JO - Experimental Brain Research

JF - Experimental Brain Research

SN - 0014-4819

IS - 3

ER -