Verbal memory impairments in children after cerebellar tumor resection

Matthew P. Kirschen, Mathew S. Davis-Ratner, Marnee W. Milner, S. H Annabel Chen, Pam Schraedley-Desmond, Paul G. Fisher, John Desmond

Research output: Contribution to journalArticle

Abstract

This study was designed to investigate cerebellar lobular contributions to specific cognitive deficits observed after cerebellar tumor resection. Verbal working memory (VWM) tasks were administered to children following surgical resection of cerebellar pilocytic astrocytomas and age-matched controls. Anatomical MRI scans were used to quantify the extent of cerebellar lobular damage from each patient's resection. Patients exhibited significantly reduced digit span for auditory but not visual stimuli, relative to controls, and damage to left hemispheral lobule VIII was significantly correlated with this deficit. Patients also showed reduced effects of articulatory suppression and this was correlated with damage to the vermis and hemispheral lobule IV/V bilaterally. Phonological similarity and recency effects did not differ overall between patients and controls, but outlier patients with abnormal phonological similarity effects to either auditory or visual stimuli were found to have damage to hemispheral lobule VIII/VIIB on the left and right, respectively. We postulate that damage to left hemispheral lobule VIII may interfere with encoding of auditory stimuli into the phonological store. These data corroborate neuroimaging studies showing focal cerebellar activation during VWM paradigms, and thereby allow us to predict with greater accuracy which specific neurocognitive processes will be affected by a cerebellar tumor resection.

Original languageEnglish (US)
Pages (from-to)39-53
Number of pages15
JournalBehavioural Neurology
Volume20
Issue number1-2
DOIs
StatePublished - 2008

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Cerebellar Neoplasms
Short-Term Memory
Astrocytoma
Neuroimaging
Magnetic Resonance Imaging

Keywords

  • Brain tumor
  • Cerebellum
  • Magnetic resonance imaging
  • Working memory

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Neurology
  • Neurology

Cite this

Kirschen, M. P., Davis-Ratner, M. S., Milner, M. W., Chen, S. H. A., Schraedley-Desmond, P., Fisher, P. G., & Desmond, J. (2008). Verbal memory impairments in children after cerebellar tumor resection. Behavioural Neurology, 20(1-2), 39-53. https://doi.org/10.3233/BEN-2008-0216

Verbal memory impairments in children after cerebellar tumor resection. / Kirschen, Matthew P.; Davis-Ratner, Mathew S.; Milner, Marnee W.; Chen, S. H Annabel; Schraedley-Desmond, Pam; Fisher, Paul G.; Desmond, John.

In: Behavioural Neurology, Vol. 20, No. 1-2, 2008, p. 39-53.

Research output: Contribution to journalArticle

Kirschen, MP, Davis-Ratner, MS, Milner, MW, Chen, SHA, Schraedley-Desmond, P, Fisher, PG & Desmond, J 2008, 'Verbal memory impairments in children after cerebellar tumor resection', Behavioural Neurology, vol. 20, no. 1-2, pp. 39-53. https://doi.org/10.3233/BEN-2008-0216
Kirschen MP, Davis-Ratner MS, Milner MW, Chen SHA, Schraedley-Desmond P, Fisher PG et al. Verbal memory impairments in children after cerebellar tumor resection. Behavioural Neurology. 2008;20(1-2):39-53. https://doi.org/10.3233/BEN-2008-0216
Kirschen, Matthew P. ; Davis-Ratner, Mathew S. ; Milner, Marnee W. ; Chen, S. H Annabel ; Schraedley-Desmond, Pam ; Fisher, Paul G. ; Desmond, John. / Verbal memory impairments in children after cerebellar tumor resection. In: Behavioural Neurology. 2008 ; Vol. 20, No. 1-2. pp. 39-53.
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