Ventricular Pacing Threshold and Time to Capture Postdefibrillation in Patients Undergoing Implantable Cardioverter‐Defibrillator Implantation

TERRANCE KHASTGIR, JOHN LATTUCA, DIANA AARONS, JOSEPH MURPHY, VICKI O'MARA, JUAN JUANTEGUY, ENRICO P. VELTRI

Research output: Contribution to journalArticle

Abstract

To assess the effect of defibrillation and amiodarone on ventricular pacing threshold and time to capture in patients undergoing automatic implantable cardioverter‐defibrillator (AICD) implantation, 28 patients were prospectively evaluated. The patients were entered into one of two protocols: la—epicardial ventricular pacing threshold measured at baseline (preventricular fibrillation induction) and 10 and 60 seconds postdefibrillation with 20 J, or Ib—two fibrillation‐defibrillation sequences were performed 3 minutes apart and ventricular pacing thresholds were measured for each sequence at baseline and at 10 and 60 seconds postdefibrillation with 20 J. Ten patients also underwent asynchronous pacing at 1.1 times baseline threshold during ventricular fibrillation with measurement of time to capture postdefibrillation. All patients were randomly assigned to receive either amiodarone or no antiarrhythmic drug therapy. Ventricular fibrillation was induced with AC (applied for 1‐2 seconds), and standard epicardial bipolar and epicardial patch electrodes of the AICD were used for pacing and defibrillation, respectively. Ventricular pacing threshold at baseline, 10 seconds, 60 seconds, and 3 minutes postdefibrillation did not differ significantly. There were no significant differences in patients with or without amiodarone therapy. Furthermore, there was no transient loss of ventricular capture postdefibrillation or significant difference in time to capture with amiodarone (≤ 2 seconds). We conclude that following internal defibrillation with 20 J: (1) ventricular pacing threshold at 10 seconds, 60 seconds, and 3 minutes were not significantly different from baseline with one or two fibrillation‐defibrillation sequences, (2) time to capture was short, and (3) there was no significant difference in no drug versus amiodarone. These findings have direct clinical importance in considering device therapy with both pacing and defibrillating capabilities.

Original languageEnglish (US)
Pages (from-to)768-772
Number of pages5
JournalPacing and Clinical Electrophysiology
Volume14
Issue number5
DOIs
StatePublished - May 1991

Keywords

  • amiodarone
  • automatic implantable cardioverter‐defibrillator

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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