Venous Thrombosis in the Broad Ligament: Is it a Predictor of Postoperative Pulmonary Embolism in Gynecological Cancer Patients? A Case-control Study

Anna V. Yemelyanova, William Winter, Jeffrey D. Seidman

Research output: Contribution to journalArticle

Abstract

Pulmonary embolism is a common postoperative complication in gynecological oncology patients and is often fatal. A substantial proportion of venous thrombi responsible for pulmonary emboli originate in the pelvic veins. The significance of thrombi in the veins of the broad ligament identified in surgical specimens is unknown. In a case-control study, women with postoperative pulmonary embolism (cases) were identified from the Gynecological Oncology service at the Washington Hospital Center and compared with consecutive surgical pathology accessions (controls). Only the broad ligament veins were evaluated for the presence of organizing thrombi. Eight patients, all of whom had a gynecological malignancy, were diagnosed postoperatively with pulmonary embolism. Six were diagnosed clinically by spiral CT from 4 to 115 days after surgery, and two were diagnosed by open lung biopsy of a new pulmonary lesion approximately 1 year postoperatively. None of the cases was shown to have thrombi in the broad ligament veins. Thrombi in the broad ligament veins were present in three of 30 control patients with malignancies. Among 56 controls without malignancies, 3 had broad ligament thrombi. These findings suggest that the presence of organizing thrombi in the broad ligament veins does not predict postoperative pulmonary embolism.

Original languageEnglish (US)
Pages (from-to)176-179
Number of pages4
JournalInternational Journal of Gynecological Pathology
Volume23
Issue number2
DOIs
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Broad Ligament
Pulmonary Embolism
Venous Thrombosis
Case-Control Studies
Thrombosis
Veins
Neoplasms
Lung
Surgical Pathology
Spiral Computed Tomography
Embolism
Ambulatory Surgical Procedures
Biopsy

Keywords

  • Broad ligament
  • Gynecological malignancies
  • Organizing thrombi
  • Postoperative pulmonary embolism
  • Pulmonary embolism

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

Cite this

Venous Thrombosis in the Broad Ligament : Is it a Predictor of Postoperative Pulmonary Embolism in Gynecological Cancer Patients? A Case-control Study. / Yemelyanova, Anna V.; Winter, William; Seidman, Jeffrey D.

In: International Journal of Gynecological Pathology, Vol. 23, No. 2, 04.2004, p. 176-179.

Research output: Contribution to journalArticle

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