Abstract
The spin-echo response to visual activation was studied as a function of spatial resolution at a field of 1.5 T. The results showed that the increase in absolute T2 upon activation was as large as 22.8 ± 3.1% (P < 0.05) at the highest resolution (5.3 mm3), while it was as small as 3.5 ± 0.2% (P < 0.05) at the lowest resolution (42.2 mm3). In addition, upon increasing resolution, the spin-echo signal decay as a function of echo time changed from monoexponential to nonexponential. These data indicate that, when using the standard resolution for fMRI studies at 1.5 T, the effects of spin-echo changes in the draining veins are of major contribution to the total blood oxygenation level-dependent (BOLD) signal changes measured in voxels encompassing the activated brain areas. The data can be quantitatively accounted for using a model based on the intravascular origin of the spin- echo effect including both macrovascular and microvascular effects. Existing theories for the spin-echo BOLD effect based on diffusion through field gradients predict negligible spin-echo effects inside the large vessels and are therefore incompatible with the data.
Original language | English (US) |
---|---|
Pages (from-to) | 617-626 |
Number of pages | 10 |
Journal | Magnetic resonance in medicine |
Volume | 42 |
Issue number | 4 |
DOIs | |
State | Published - 1999 |
Keywords
- Blood oxygenation level-dependent
- Brain
- Functional MRI
- Spin echo
- Venous blood
- Visual cortex
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging