VCL-ALK renal cell carcinoma in children with sickle-cell trait

The eighth sickle-cell nephropathy?

Nathaniel E. Smith, Andrea T. Deyrup, Adrian Mariño-Enriquez, Jonathan A. Fletcher, Julia A. Bridge, Peter B Illei, George J. Netto, Pedram Argani

Research output: Contribution to journalArticle

Abstract

We report the third case of a renal cell carcinoma bearing a fusion of the vinculin (VCL) and anaplastic lymphoma kinase (ALK) genes. Like the 2 other reported cases, this neoplasm occurred in a young patient (6 y old) with sickle-cell trait and demonstrated distinctive morphologic features including medullary epicenter, discohesive polygonal or spindle-shaped cells with prominent cytoplasmic vacuoles, and prominent lymphocytic infiltrate. The neoplastic cells demonstrated focal membranous labeling for ALK protein by immunohistochemistry, ALK gene rearrangement by fluorescence in situ hybridization, and a specific VCL-ALK gene fusion by reverse transcriptase polymerase chain reaction. VCL-ALK renal cell carcinoma may represent the eighth sickle-cell nephropathy.

Original languageEnglish (US)
Pages (from-to)858-863
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume38
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Sickle Cell Trait
Vinculin
Renal Cell Carcinoma
Gene Rearrangement
Gene Fusion
Vacuoles
Reverse Transcriptase Polymerase Chain Reaction
Fluorescence In Situ Hybridization
Immunohistochemistry
anaplastic lymphoma kinase
Genes
Neoplasms
Proteins

Keywords

  • Anaplastic lymphoma kinase
  • Renal cell carcinoma
  • Vinculin

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

VCL-ALK renal cell carcinoma in children with sickle-cell trait : The eighth sickle-cell nephropathy? / Smith, Nathaniel E.; Deyrup, Andrea T.; Mariño-Enriquez, Adrian; Fletcher, Jonathan A.; Bridge, Julia A.; Illei, Peter B; Netto, George J.; Argani, Pedram.

In: American Journal of Surgical Pathology, Vol. 38, No. 6, 2014, p. 858-863.

Research output: Contribution to journalArticle

Smith, Nathaniel E. ; Deyrup, Andrea T. ; Mariño-Enriquez, Adrian ; Fletcher, Jonathan A. ; Bridge, Julia A. ; Illei, Peter B ; Netto, George J. ; Argani, Pedram. / VCL-ALK renal cell carcinoma in children with sickle-cell trait : The eighth sickle-cell nephropathy?. In: American Journal of Surgical Pathology. 2014 ; Vol. 38, No. 6. pp. 858-863.
@article{2aba67ce74b44e0e8223c973a2a12d11,
title = "VCL-ALK renal cell carcinoma in children with sickle-cell trait: The eighth sickle-cell nephropathy?",
abstract = "We report the third case of a renal cell carcinoma bearing a fusion of the vinculin (VCL) and anaplastic lymphoma kinase (ALK) genes. Like the 2 other reported cases, this neoplasm occurred in a young patient (6 y old) with sickle-cell trait and demonstrated distinctive morphologic features including medullary epicenter, discohesive polygonal or spindle-shaped cells with prominent cytoplasmic vacuoles, and prominent lymphocytic infiltrate. The neoplastic cells demonstrated focal membranous labeling for ALK protein by immunohistochemistry, ALK gene rearrangement by fluorescence in situ hybridization, and a specific VCL-ALK gene fusion by reverse transcriptase polymerase chain reaction. VCL-ALK renal cell carcinoma may represent the eighth sickle-cell nephropathy.",
keywords = "Anaplastic lymphoma kinase, Renal cell carcinoma, Vinculin",
author = "Smith, {Nathaniel E.} and Deyrup, {Andrea T.} and Adrian Mari{\~n}o-Enriquez and Fletcher, {Jonathan A.} and Bridge, {Julia A.} and Illei, {Peter B} and Netto, {George J.} and Pedram Argani",
year = "2014",
doi = "10.1097/PAS.0000000000000179",
language = "English (US)",
volume = "38",
pages = "858--863",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - VCL-ALK renal cell carcinoma in children with sickle-cell trait

T2 - The eighth sickle-cell nephropathy?

AU - Smith, Nathaniel E.

AU - Deyrup, Andrea T.

AU - Mariño-Enriquez, Adrian

AU - Fletcher, Jonathan A.

AU - Bridge, Julia A.

AU - Illei, Peter B

AU - Netto, George J.

AU - Argani, Pedram

PY - 2014

Y1 - 2014

N2 - We report the third case of a renal cell carcinoma bearing a fusion of the vinculin (VCL) and anaplastic lymphoma kinase (ALK) genes. Like the 2 other reported cases, this neoplasm occurred in a young patient (6 y old) with sickle-cell trait and demonstrated distinctive morphologic features including medullary epicenter, discohesive polygonal or spindle-shaped cells with prominent cytoplasmic vacuoles, and prominent lymphocytic infiltrate. The neoplastic cells demonstrated focal membranous labeling for ALK protein by immunohistochemistry, ALK gene rearrangement by fluorescence in situ hybridization, and a specific VCL-ALK gene fusion by reverse transcriptase polymerase chain reaction. VCL-ALK renal cell carcinoma may represent the eighth sickle-cell nephropathy.

AB - We report the third case of a renal cell carcinoma bearing a fusion of the vinculin (VCL) and anaplastic lymphoma kinase (ALK) genes. Like the 2 other reported cases, this neoplasm occurred in a young patient (6 y old) with sickle-cell trait and demonstrated distinctive morphologic features including medullary epicenter, discohesive polygonal or spindle-shaped cells with prominent cytoplasmic vacuoles, and prominent lymphocytic infiltrate. The neoplastic cells demonstrated focal membranous labeling for ALK protein by immunohistochemistry, ALK gene rearrangement by fluorescence in situ hybridization, and a specific VCL-ALK gene fusion by reverse transcriptase polymerase chain reaction. VCL-ALK renal cell carcinoma may represent the eighth sickle-cell nephropathy.

KW - Anaplastic lymphoma kinase

KW - Renal cell carcinoma

KW - Vinculin

UR - http://www.scopus.com/inward/record.url?scp=84900847567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900847567&partnerID=8YFLogxK

U2 - 10.1097/PAS.0000000000000179

DO - 10.1097/PAS.0000000000000179

M3 - Article

VL - 38

SP - 858

EP - 863

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 6

ER -