Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) pathway initiated by t cell antigen receptor (TCRγλ) activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γλT cell cytotoxicity

Shanshan Yin, Jianmin Zhang, Yujia Mao, Yu Hu, Lianxian Cui, Ning Kang, Wei He

Research output: Contribution to journalArticle

Abstract

Background: TCRγλ and NKG2D are two important receptors for γλT cell cytotoxicity. Results: γλT cell cytotoxicity is TCRγλ-dependent and requires the activation of Vav1-PLC-γ1 pathway. Conclusion: γλT cell cytotoxicity requires a strong signal to overcome the inhibitory threshold set by Cbl-b. Significance: Our finding provides new insights into the molecular mechanisms underlying the activation of γλT cell cytotoxicity.

Original languageEnglish (US)
Pages (from-to)26448-26462
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number37
DOIs
StatePublished - Sep 13 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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