Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) pathway initiated by t cell antigen receptor (TCRγλ) activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γλT cell cytotoxicity

Shanshan Yin; Jianmin Zhang; Yujia Mao; Yu Hu; Lianxian Cui; Ning Kang; Wei He

doi:10.1074/jbc.M113.484600

Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) pathway initiated by t cell antigen receptor (TCRγλ) activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γλT cell cytotoxicity

Shanshan Yin, Jianmin Zhang, Yujia Mao, Yu Hu, Lianxian Cui, Ning Kang, Wei He

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: TCRγλ and NKG2D are two important receptors for γλT cell cytotoxicity. Results: γλT cell cytotoxicity is TCRγλ-dependent and requires the activation of Vav1-PLC-γ1 pathway. Conclusion: γλT cell cytotoxicity requires a strong signal to overcome the inhibitory threshold set by Cbl-b. Significance: Our finding provides new insights into the molecular mechanisms underlying the activation of γλT cell cytotoxicity.

Original language	English (US)
Pages (from-to)	26448-26462
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	37
DOIs	https://doi.org/10.1074/jbc.M113.484600
State	Published - Sep 13 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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10.1074/jbc.M113.484600

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Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) pathway initiated by t cell antigen receptor (TCRγλ) activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γλT cell cytotoxicity. / Yin, Shanshan; Zhang, Jianmin; Mao, Yujia et al.
In: Journal of Biological Chemistry, Vol. 288, No. 37, 13.09.2013, p. 26448-26462.

Research output: Contribution to journal › Article › peer-review

Yin, S, Zhang, J, Mao, Y, Hu, Y, Cui, L, Kang, N & He, W 2013, 'Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) pathway initiated by t cell antigen receptor (TCRγλ) activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γλT cell cytotoxicity', Journal of Biological Chemistry, vol. 288, no. 37, pp. 26448-26462. https://doi.org/10.1074/jbc.M113.484600

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abstract = "Background: TCRγλ and NKG2D are two important receptors for γλT cell cytotoxicity. Results: γλT cell cytotoxicity is TCRγλ-dependent and requires the activation of Vav1-PLC-γ1 pathway. Conclusion: γλT cell cytotoxicity requires a strong signal to overcome the inhibitory threshold set by Cbl-b. Significance: Our finding provides new insights into the molecular mechanisms underlying the activation of γλT cell cytotoxicity.",

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AU - Yin, Shanshan

AU - Zhang, Jianmin

AU - Mao, Yujia

AU - Hu, Yu

AU - Cui, Lianxian

AU - Kang, Ning

AU - He, Wei

PY - 2013/9/13

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AB - Background: TCRγλ and NKG2D are two important receptors for γλT cell cytotoxicity. Results: γλT cell cytotoxicity is TCRγλ-dependent and requires the activation of Vav1-PLC-γ1 pathway. Conclusion: γλT cell cytotoxicity requires a strong signal to overcome the inhibitory threshold set by Cbl-b. Significance: Our finding provides new insights into the molecular mechanisms underlying the activation of γλT cell cytotoxicity.

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Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) pathway initiated by t cell antigen receptor (TCRγλ) activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γλT cell cytotoxicity

Abstract

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