TY - JOUR
T1 - Vasospasm after subarachnoid hemorrhage in haptoglobin 2-2 mice can be prevented with a glutathione peroxidase mimetic
AU - Froehler, Michael T.
AU - Kooshkabadi, Ali
AU - Miller-Lotan, Rachel
AU - Blum, Shany
AU - Sher, Slava
AU - Levy, Andrew
AU - Tamargo, Rafael J.
N1 - Funding Information:
This project was funded by a gift from the Rosenberg family and Mr and Mrs J. Dorsey Brown to R.J.T. and by the Walter E. Dandy, M.D. Endowment to R.J.T. M.T.F. is currently supported by a grant from the A.P. Giannini Foundation.
PY - 2010/9
Y1 - 2010/9
N2 - Vasospasm after subarachnoid hemorrhage (SAH) is attributable to inflammation and oxidative stress associated with extracellular hemoglobin (Hb). Haptoglobin (Hp) binds free Hb and the Hp-Hb complex is cleared by macrophages, and the Hp-2 isoform of Hp is associated with more oxidative stress and more severe vasospasm. We hypothesized that treatment with an anti-oxidant, the glutathione peroxidase mimetic SYI-2074, would reduce vasospasm after SAH in Hp-2 mice. We found that SAH induced significant vasospasm in Hp-2 mice (lumen patency reduced to 65.9%), but no vasospasm was seen in mice that received SYI-2074 after SAH (lumen patency of 98.7%). We conclude that vasospasm after SAH in Hp-2 mice can be prevented with SYI-2074, suggesting that oxidative stress contributes significantly to vasospasm.
AB - Vasospasm after subarachnoid hemorrhage (SAH) is attributable to inflammation and oxidative stress associated with extracellular hemoglobin (Hb). Haptoglobin (Hp) binds free Hb and the Hp-Hb complex is cleared by macrophages, and the Hp-2 isoform of Hp is associated with more oxidative stress and more severe vasospasm. We hypothesized that treatment with an anti-oxidant, the glutathione peroxidase mimetic SYI-2074, would reduce vasospasm after SAH in Hp-2 mice. We found that SAH induced significant vasospasm in Hp-2 mice (lumen patency reduced to 65.9%), but no vasospasm was seen in mice that received SYI-2074 after SAH (lumen patency of 98.7%). We conclude that vasospasm after SAH in Hp-2 mice can be prevented with SYI-2074, suggesting that oxidative stress contributes significantly to vasospasm.
KW - Glutathione peroxidase
KW - Haptoglobin
KW - Subarachnoid hemorrhage
KW - Vasospasm
UR - http://www.scopus.com/inward/record.url?scp=77955550384&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955550384&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2010.04.014
DO - 10.1016/j.jocn.2010.04.014
M3 - Article
C2 - 20541941
AN - SCOPUS:77955550384
SN - 0967-5868
VL - 17
SP - 1169
EP - 1172
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 9
ER -