Vasospasm after subarachnoid hemorrhage in haptoglobin 2-2 mice can be prevented with a glutathione peroxidase mimetic

Michael T. Froehler, Ali Kooshkabadi, Rachel Miller-Lotan, Shany Blum, Slava Sher, Andrew Levy, Rafael J. Tamargo

Research output: Contribution to journalArticlepeer-review

Abstract

Vasospasm after subarachnoid hemorrhage (SAH) is attributable to inflammation and oxidative stress associated with extracellular hemoglobin (Hb). Haptoglobin (Hp) binds free Hb and the Hp-Hb complex is cleared by macrophages, and the Hp-2 isoform of Hp is associated with more oxidative stress and more severe vasospasm. We hypothesized that treatment with an anti-oxidant, the glutathione peroxidase mimetic SYI-2074, would reduce vasospasm after SAH in Hp-2 mice. We found that SAH induced significant vasospasm in Hp-2 mice (lumen patency reduced to 65.9%), but no vasospasm was seen in mice that received SYI-2074 after SAH (lumen patency of 98.7%). We conclude that vasospasm after SAH in Hp-2 mice can be prevented with SYI-2074, suggesting that oxidative stress contributes significantly to vasospasm.

Original languageEnglish (US)
Pages (from-to)1169-1172
Number of pages4
JournalJournal of Clinical Neuroscience
Volume17
Issue number9
DOIs
StatePublished - Sep 2010

Keywords

  • Glutathione peroxidase
  • Haptoglobin
  • Subarachnoid hemorrhage
  • Vasospasm

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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