Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans

Caroline F. Zink, Jason L. Stein, Lucas Kempf, Shabnam Hakimi, Andreas Meyer-Lindenberg

Research output: Contribution to journalArticle

Abstract

The neuropeptide vasopressin is a modulator of mammalian social behavior and emotion, particularly fear, aggression, and anxiety. In humans, the neural circuitry underlying behavioral effects of vasopressin is unknown. Using a double-blind crossover administration of 40 IU of vasopressin or placebo and functional MRI during processing of facial emotions in healthy male volunteers, we show that vasopressin specifically reduces differential activation in the subgenual cingulate cortex. Structural equation modeling of a previously evaluated circuit between amygdala, subgenual cingulate, and supragenual cingulate revealed altered effective connectivity between subgenual and supragenual cingulate under vasopressin. Our data demonstrate an impact of vasopressin on activity and connectivity in the cortical component of a medial prefrontal cortex-amygdala circuit implicated in emotional regulation, providing the first data on the neural basis for the effects of vasopressin on social behavior in humans with potential therapeutic significance for mood and anxiety disorders.

Original languageEnglish (US)
Pages (from-to)7017-7022
Number of pages6
JournalJournal of Neuroscience
Volume30
Issue number20
DOIs
StatePublished - May 19 2010
Externally publishedYes

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Amygdala
Prefrontal Cortex
Vasopressins
Emotions
Social Behavior
Gyrus Cinguli
Anxiety Disorders
Neuropeptides
Aggression
Mood Disorders
Fear
Healthy Volunteers
Anxiety
Placebos
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans. / Zink, Caroline F.; Stein, Jason L.; Kempf, Lucas; Hakimi, Shabnam; Meyer-Lindenberg, Andreas.

In: Journal of Neuroscience, Vol. 30, No. 20, 19.05.2010, p. 7017-7022.

Research output: Contribution to journalArticle

Zink, Caroline F. ; Stein, Jason L. ; Kempf, Lucas ; Hakimi, Shabnam ; Meyer-Lindenberg, Andreas. / Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 20. pp. 7017-7022.
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