Vasopressin binds to microvessels from rat hippocampus

Roswitha Kretzschmar, R. Landgraf, A. Gjedde, A. Ermisch

Research output: Contribution to journalArticlepeer-review

Abstract

Recent evidence suggests that vasopressin may influence the permeability of the endothelium of brain capillaries. We measured the binding of [125I]arginine-8-vasopressin ([125I]AVP) to microvessels isolated from different regions of the rat brain. The study revealed saturable and specific binding of [125I]AVP to microvessels isolated from hippocampus. Scatchard analysis confirmed a single class of high affinity sites with an equilibrium dissociation constant, Kd, of 3.2 nM and an apparent maximal binding capacity of 205 fmol/mg protein. No binding was observed to microvessels from neocortex and striatum.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
JournalBrain research
Volume380
Issue number2
DOIs
StatePublished - Aug 20 1986

Keywords

  • binding site
  • blood-brain barrier
  • microvessel
  • vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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