Vasopressin and oxytocin gene expression in the human hypothalamus

R. R. Sukhov, L. C. Walker, N. E. Rance, D. L. Price, W. S. Young

Research output: Contribution to journalArticle

Abstract

We studied the distribution of messenger ribonucleic acids coding for vasopressin and oxytocin in the human hypothalamus by means of hybridization histochemistry. Numerous large and medium-sized neurons contain vasopressin messenger ribonucleic acid in the paraventricular nucleus, supraoptic nucleus, and accessory magnocellular nucleus. Small, lightly labeled vasopressin neurons also were detected in the suprachiasmatic nucleus. In addition, a relatively sparse band of mostly ovoid, medium-sized vasopressin neurons mingle with unlabeled neurons of the lateral hypothalamic area; these cells extend dorsoventrally from the region ventral to the stria terminalis to the ventrolateral hypothalamus, sometimes transgressing the boundaries of nearby nuclei. We did not detect vasopressin gene expression in neurons of the bed nucleus of the stria terminalis proper, although some of the dorsal- most labeled neurons of the lateral hypothalamus extend into the region of the caudal bed nucleus. Some lateral hypothalamic neurons also encroach upon other extrahypothalamic structures, such as the zona incerta. The nucleus basalis of Meynert complex was, with only rare exceptions, devoid of cells containing vasopressin messenger ribonucleic acid. Oxytocin messenger ribonucleic acid is found in the supraoptic nucleus, paraventricular nucleus, accessory magnocellular nucleus and, less frequently, in neurons of the lateral hypothalamus. In the hypothalamic magnocellular nuclei, oxytocin neurons are somewhat smaller than vasopressin neurons. Vasopressin cells outnumber oxytocin cells in the supraoptic nucleus, but their numbers are comparable in the paraventricular nucleus. As with vasopressin neurons, lateral hypothalamic oxytocin cells loosely span several diencephalic nuclei and encroach occasionally upon adjacent regions. These results confirm that the organization of vasopressin and oxytocin neurons in the human hypothalamus is largely comparable to that in nonhuman species and demonstrate the utility of hybridization histochemistry for elucidating the chemoarchitecture of the human brain.

Original languageEnglish (US)
Pages (from-to)295-306
Number of pages12
JournalJournal of Comparative Neurology
Volume337
Issue number2
DOIs
StatePublished - 1993

Fingerprint

Oxytocin
Vasopressins
Hypothalamus
Gene Expression
Neurons
Lateral Hypothalamic Area
Supraoptic Nucleus
Paraventricular Hypothalamic Nucleus
RNA
Basal Nucleus of Meynert
Septal Nuclei
Suprachiasmatic Nucleus

Keywords

  • basal forebrain
  • in situ hybridization histochemistry
  • paraventricular nucleus
  • suprachiasmatic nucleus
  • supraoptic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sukhov, R. R., Walker, L. C., Rance, N. E., Price, D. L., & Young, W. S. (1993). Vasopressin and oxytocin gene expression in the human hypothalamus. Journal of Comparative Neurology, 337(2), 295-306. https://doi.org/10.1002/cne.903370210

Vasopressin and oxytocin gene expression in the human hypothalamus. / Sukhov, R. R.; Walker, L. C.; Rance, N. E.; Price, D. L.; Young, W. S.

In: Journal of Comparative Neurology, Vol. 337, No. 2, 1993, p. 295-306.

Research output: Contribution to journalArticle

Sukhov, RR, Walker, LC, Rance, NE, Price, DL & Young, WS 1993, 'Vasopressin and oxytocin gene expression in the human hypothalamus', Journal of Comparative Neurology, vol. 337, no. 2, pp. 295-306. https://doi.org/10.1002/cne.903370210
Sukhov, R. R. ; Walker, L. C. ; Rance, N. E. ; Price, D. L. ; Young, W. S. / Vasopressin and oxytocin gene expression in the human hypothalamus. In: Journal of Comparative Neurology. 1993 ; Vol. 337, No. 2. pp. 295-306.
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