Vasodilation due to urokinase in canine femoral circulation

N. J. Gurll, M. J. Zinner, W. Callahan, D. G. Reynolds

Research output: Contribution to journalArticle

Abstract

Based upon clinical observations, we hypothesize that the plasminogen activator urokinase is vasoactive in addition to being fibrinolytic and thrombolytic. The effects of intra-arterial injections and infusions of urokinase were investigated in the canine femoral circulation. Injections of human urine urokinase increased femoral artery blood flow in a dose-related fashion that was not significantly attenuated by β adrenergic blockade, antihistamine treatment, heating, atropine treatment or kallikrein inactivation. The Ploug preparation of urine urokinase was somewhat more effective than the Abbott or Sterling-Winthrop preparations in causing this dilation. Some nonspecific inhibition of the vasodilator responses was produced by inhibition of plasminogen activation with ε-aminocaproic acid. The continuous infusion of urokinase increased femoral arterial flow but there was some tendency to escape. Further experiments seem indicated to determine potential application of local urokinase in clinical conditions where vasodilation and fibriolysis-thrombolysis might be of value.

Original languageEnglish (US)
Pages (from-to)731-737
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume201
Issue number3
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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    Gurll, N. J., Zinner, M. J., Callahan, W., & Reynolds, D. G. (1977). Vasodilation due to urokinase in canine femoral circulation. Journal of Pharmacology and Experimental Therapeutics, 201(3), 731-737.