Vaso-occlusive Retinopathy Associated with Anti-phospholipid Antibodies (lupus anticoagulant retinopathy)

Robert C. Kleiner, Lawrence V. Najarian, Sam Schatten, Douglas A. Jabs, Arnall Patz, Henry J. Kaplan

Research output: Contribution to journalArticlepeer-review


The authors observed three cases (6 eyes) of vaso-occlusive retinopathy associated with the lupus anticoagulant and the related antiphospholipid antibody anticardiolipin. The disease occurred in patients who had no definable autoimmune disease such as systemic lupus erythematosus (SLE) and was characterized by severe bilateral retinal vascular occlusion. There was profound visual loss from intraretinal ischemia as well as vitreous hemorrhage from preretinal neovascularization. Results of laboratory testing showed a prolonged partial thromboplastin time (PTT) in two patients, and the presence of the lupus anticoagulant in all. Treatment with panretinal photocoagulation appeared to stabilize the neovascularization. The role of systemic anticoagulation and immunosuppressive therapy is uncertain. Ophthalmology 96:896-904,1989

Original languageEnglish (US)
Pages (from-to)896-904
Number of pages9
Issue number6
StatePublished - 1989

ASJC Scopus subject areas

  • Ophthalmology


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