Vasculitides D. immune complex-mediated vasculitis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pathogenic immune complexes formed between antigen and antibodies tend to occur during periods of antigen excess. When the immune complexes precipitate into the tissues, they fix complement, leading to an intense immune reaction. In immune complex vasculitis, immune complexes deposit in the vascular endothelium or in capillary beds, such as those found in the skin, kidneys, or lungs. The most common skin manifestation of small vessel vasculitis is palpable purpura. Hypersensitivity vasculitis is characterized by immune complex deposition in capillaries, postcapillary venules, and arterioles. The usual causes are either medications (e.g., penicillins, sulfonamides, or cephalosporins) or infections. Cryoglobulinemic vasculitis is usually caused by hepatitis C infections. The antigens involved in cryoglobulinemic vasculitis are portions of the hepatitis C virus (HCV) virion. The relevant antibodies are both IgG and IgM, leading to the designation mixed cryoglobulinemia. Henoch-Schönlein purpura is associated strongly with IgA deposition within blood vessel walls. Hypocomplementemic urticarial vasculitis has many features that overlap with systemic lupus erythematosus.

Original languageEnglish (US)
Title of host publicationPrimer on the Rheumatic Diseases: Thirteenth Edition
PublisherSpringer New York
Pages427-434
Number of pages8
ISBN (Print)9780387356648
DOIs
StatePublished - 2008

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Vasculitis
Antigen-Antibody Complex
Antigens
Cutaneous Leukocytoclastic Vasculitis
Skin Manifestations
Cryoglobulinemia
Schoenlein-Henoch Purpura
Precipitins
Purpura
Venules
Antibodies
Sulfonamides
Vascular Endothelium
Arterioles
Cephalosporins
Hepatitis C
Infection
Hepacivirus
Penicillins
Virion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Seo, P. (2008). Vasculitides D. immune complex-mediated vasculitis. In Primer on the Rheumatic Diseases: Thirteenth Edition (pp. 427-434). Springer New York. https://doi.org/10.1007/978-0-387-68566-3_54

Vasculitides D. immune complex-mediated vasculitis. / Seo, Philip.

Primer on the Rheumatic Diseases: Thirteenth Edition. Springer New York, 2008. p. 427-434.

Research output: Chapter in Book/Report/Conference proceedingChapter

Seo, P 2008, Vasculitides D. immune complex-mediated vasculitis. in Primer on the Rheumatic Diseases: Thirteenth Edition. Springer New York, pp. 427-434. https://doi.org/10.1007/978-0-387-68566-3_54
Seo P. Vasculitides D. immune complex-mediated vasculitis. In Primer on the Rheumatic Diseases: Thirteenth Edition. Springer New York. 2008. p. 427-434 https://doi.org/10.1007/978-0-387-68566-3_54
Seo, Philip. / Vasculitides D. immune complex-mediated vasculitis. Primer on the Rheumatic Diseases: Thirteenth Edition. Springer New York, 2008. pp. 427-434
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