TY - JOUR
T1 - Vascularized and Innervated Skeletal Muscle Tissue Engineering
AU - Gilbert-Honick, Jordana
AU - Grayson, Warren
N1 - Funding Information:
Funding was provided by the NIH (NIAMS NRSA F31) to J.G.-H. and the Maryland Stem Cell Research Fund (2016-MSCRFI-2692) to W.G. The authors would like to thank Shawna Snyder for providing original schematics.
Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully recover the lost muscle tissue and function. Tissue engineering presents a promising solution for VML treatment and significant research has been performed using tissue engineered muscle constructs in preclinical models of VML with a broad range of defect locations and sizes, tissue engineered construct characteristics, and outcome measures. Due to the complex vascular and neural anatomy within skeletal muscle, regeneration of functional vasculature and nerves is vital for muscle recovery following VML injuries. This review aims to summarize the current state of the field of skeletal muscle tissue engineering using 3D constructs for VML treatment with a focus on studies that have promoted vascular and neural regeneration within the muscle tissue post-VML.
AB - Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully recover the lost muscle tissue and function. Tissue engineering presents a promising solution for VML treatment and significant research has been performed using tissue engineered muscle constructs in preclinical models of VML with a broad range of defect locations and sizes, tissue engineered construct characteristics, and outcome measures. Due to the complex vascular and neural anatomy within skeletal muscle, regeneration of functional vasculature and nerves is vital for muscle recovery following VML injuries. This review aims to summarize the current state of the field of skeletal muscle tissue engineering using 3D constructs for VML treatment with a focus on studies that have promoted vascular and neural regeneration within the muscle tissue post-VML.
KW - neuromuscular junctions
KW - skeletal muscle regeneration
KW - tissue engineering
KW - vascularization
KW - volumetric muscle loss
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U2 - 10.1002/adhm.201900626
DO - 10.1002/adhm.201900626
M3 - Review article
C2 - 31622051
AN - SCOPUS:85074294585
SN - 2192-2640
VL - 9
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 1
M1 - 1900626
ER -