Vascular stiffness and increased pulse pressure in the aging cardiovascular system

Daniel Nyhan, Jochen Steppan, Viachaslau Barodka, Dan E. Berkowitz

Research output: Contribution to journalReview articlepeer-review

Abstract

Aging leads to a multitude of changes in the cardiovascular system, including systolic hypertension, increased central vascular stiffness, and increased pulse pressure. In this paper we will review the effects of age-associated increased vascular stiffness on systolic blood pressure, pulse pressure, augmentation index, and cardiac workload. Additionally we will describe pulse wave velocity as a method to measure vascular stiffness and review the impact of increased vascular stiffness as an index of vascular health and as a predictor of adverse cardiovascular outcomes. Furthermore, we will discuss the underlying mechanisms and how these may be modified in order to change the outcomes. A thorough understanding of these concepts is of paramount importance and has therapeutic implications for the increasingly elderly population.

Original languageEnglish (US)
Article number263585
JournalCardiology Research and Practice
Volume1
Issue number1
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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