Vascular space occupancy(VASO) cerebral blood volume-weighted MRI identifies hemodynamic impairment in patients with carotid artery disease

Manus J. Donahue, Peter Jan Van Laar, Peter C Van Zijl, Robert David Stevens, Jeroen Hendrikse

Research output: Contribution to journalArticle

Abstract

Purpose: To assess the role of vascular space occupancy(VASO) magnetic resonance imaging(MRI), a noninvasive cerebral blood volume(CBV)-weighted technique, for evaluating CBV reactivity in patients with internal carotid artery(ICA) stenosis. Materials and Methods: VASO reactivity, defined as a signal change in response to hypercapnic stimulus(4-second exhale, 14-second breath-hold), was measured in the left and right ICA flow territories in patients(n = 10) with varying degrees ofunilateral and bilateral ICAstenosis and in healthy volunteers(n = 10). Results: Percent VASO reactivity was more negative(P

Original languageEnglish (US)
Pages (from-to)718-724
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume29
Issue number3
DOIs
StatePublished - Mar 2009

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Carotid Artery Diseases
Blood Vessels
Hemodynamics
Magnetic Resonance Imaging
Carotid Stenosis
Internal Carotid Artery
Healthy Volunteers
Cerebral Blood Volume

Keywords

  • Autoregulation
  • CBF
  • CBV
  • Stenosis
  • Stroke
  • VASO

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Vascular space occupancy(VASO) cerebral blood volume-weighted MRI identifies hemodynamic impairment in patients with carotid artery disease. / Donahue, Manus J.; Van Laar, Peter Jan; Van Zijl, Peter C; Stevens, Robert David; Hendrikse, Jeroen.

In: Journal of Magnetic Resonance Imaging, Vol. 29, No. 3, 03.2009, p. 718-724.

Research output: Contribution to journalArticle

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