Vascular responses to hypoxia and ischemia

Research output: Contribution to journalReview articlepeer-review

Abstract

Blood vessels function as conduits for the delivery of O2 and nutrients. Hypoxia-inducible factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia that include expression of angiogenic cytokines/growth factors by hypoxic cells and expression of cognate receptors for these ligands by vascular cells and their progenitors. Impairment of HIF-1-dependent responses to hypoxia is a major factor contributing to the impaired vascular responses to ischemia that are associated with aging and diabetes.

Original languageEnglish (US)
Pages (from-to)648-652
Number of pages5
JournalArteriosclerosis, thrombosis, and vascular biology
Volume30
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • Angiogenesis
  • Gene therapy
  • Hypoxia
  • Ischemia
  • Ischemic biology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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