Vascular involvement of the central nervous system and systemic diseases: Etiologies and MRI findings

Simone Appenzeller, Andreia Vasconcellos Faria, Verônica A. Zanardi, Sandra R. Fernandes, Lilian Tereza Lavras Costallat, Fernando Cendes

Research output: Contribution to journalArticle

Abstract

The objective of this study was to review magnetic resonance imaging (MRI) findings in patients with vascular involvement of the central nervous system (CNS) associated with systemic diseases. We reviewed the MRI findings in clinically suspected cases of vascular involvement of the CNS associated with systemic diseases. Vascular CNS involvement was considered in the presence of characteristic clinical, MRI and/or MR angiography findings. In order to be included in the study, patients needed to have a complete clinical and laboratory investigation and a follow-up of a minimum of 6 months. Twenty-four patients (17 women and 7 men), with mean age of 29.5 years had diagnosis of CNS vasculitis and were included. The clinical presentation was variable, but the most common complaints were headache in 18, focal deficits in 9, disturbances of consciousness in 9, and seizures in 8 patients. Underlying causes for CNS vasculitis were identified in all patients and included systemic lupus erythematosus in eight, tuberculosis in three, bacterial meningitis in three, Takayasu arteritis in two, polyarteritis nodosa in two, syphilis in two, drug abuse in two, yellow fever in one and varicella in one patient. Nonspecific high intensity T2WI/FLAIR lesions in white matter were the most common finding, present in ten patients. Eight patients had infarctions in large cerebral arteries territory, associated or not with high intensity T2WI/FLAIR small foci. Vascular involvement of the CNS can be found in a great variety of systemic diseases, including rheumatologic, infectious and drug abuse. Clinical findings are unspecific and MRI/MRA may help to establish the correct diagnosis.

Original languageEnglish (US)
Pages (from-to)1229-1237
Number of pages9
JournalRheumatology International
Volume28
Issue number12
DOIs
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

Central Nervous System Diseases
Blood Vessels
Magnetic Resonance Imaging
Central Nervous System
Central Nervous System Vasculitis
Substance-Related Disorders
Yellow Fever
Takayasu Arteritis
Polyarteritis Nodosa
Bacterial Meningitides
Cerebral Arteries
Chickenpox
Syphilis
Consciousness
Systemic Lupus Erythematosus
Infarction
Headache
Angiography
Seizures
Tuberculosis

Keywords

  • Central nervous system
  • Magnetic resonance imaging
  • Vaculitis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Vascular involvement of the central nervous system and systemic diseases : Etiologies and MRI findings. / Appenzeller, Simone; Faria, Andreia Vasconcellos; Zanardi, Verônica A.; Fernandes, Sandra R.; Costallat, Lilian Tereza Lavras; Cendes, Fernando.

In: Rheumatology International, Vol. 28, No. 12, 10.2008, p. 1229-1237.

Research output: Contribution to journalArticle

Appenzeller, Simone ; Faria, Andreia Vasconcellos ; Zanardi, Verônica A. ; Fernandes, Sandra R. ; Costallat, Lilian Tereza Lavras ; Cendes, Fernando. / Vascular involvement of the central nervous system and systemic diseases : Etiologies and MRI findings. In: Rheumatology International. 2008 ; Vol. 28, No. 12. pp. 1229-1237.
@article{8d99637c4158412d8da0241c19736e8d,
title = "Vascular involvement of the central nervous system and systemic diseases: Etiologies and MRI findings",
abstract = "The objective of this study was to review magnetic resonance imaging (MRI) findings in patients with vascular involvement of the central nervous system (CNS) associated with systemic diseases. We reviewed the MRI findings in clinically suspected cases of vascular involvement of the CNS associated with systemic diseases. Vascular CNS involvement was considered in the presence of characteristic clinical, MRI and/or MR angiography findings. In order to be included in the study, patients needed to have a complete clinical and laboratory investigation and a follow-up of a minimum of 6 months. Twenty-four patients (17 women and 7 men), with mean age of 29.5 years had diagnosis of CNS vasculitis and were included. The clinical presentation was variable, but the most common complaints were headache in 18, focal deficits in 9, disturbances of consciousness in 9, and seizures in 8 patients. Underlying causes for CNS vasculitis were identified in all patients and included systemic lupus erythematosus in eight, tuberculosis in three, bacterial meningitis in three, Takayasu arteritis in two, polyarteritis nodosa in two, syphilis in two, drug abuse in two, yellow fever in one and varicella in one patient. Nonspecific high intensity T2WI/FLAIR lesions in white matter were the most common finding, present in ten patients. Eight patients had infarctions in large cerebral arteries territory, associated or not with high intensity T2WI/FLAIR small foci. Vascular involvement of the CNS can be found in a great variety of systemic diseases, including rheumatologic, infectious and drug abuse. Clinical findings are unspecific and MRI/MRA may help to establish the correct diagnosis.",
keywords = "Central nervous system, Magnetic resonance imaging, Vaculitis",
author = "Simone Appenzeller and Faria, {Andreia Vasconcellos} and Zanardi, {Ver{\^o}nica A.} and Fernandes, {Sandra R.} and Costallat, {Lilian Tereza Lavras} and Fernando Cendes",
year = "2008",
month = "10",
doi = "10.1007/s00296-008-0647-z",
language = "English (US)",
volume = "28",
pages = "1229--1237",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer Verlag",
number = "12",

}

TY - JOUR

T1 - Vascular involvement of the central nervous system and systemic diseases

T2 - Etiologies and MRI findings

AU - Appenzeller, Simone

AU - Faria, Andreia Vasconcellos

AU - Zanardi, Verônica A.

AU - Fernandes, Sandra R.

AU - Costallat, Lilian Tereza Lavras

AU - Cendes, Fernando

PY - 2008/10

Y1 - 2008/10

N2 - The objective of this study was to review magnetic resonance imaging (MRI) findings in patients with vascular involvement of the central nervous system (CNS) associated with systemic diseases. We reviewed the MRI findings in clinically suspected cases of vascular involvement of the CNS associated with systemic diseases. Vascular CNS involvement was considered in the presence of characteristic clinical, MRI and/or MR angiography findings. In order to be included in the study, patients needed to have a complete clinical and laboratory investigation and a follow-up of a minimum of 6 months. Twenty-four patients (17 women and 7 men), with mean age of 29.5 years had diagnosis of CNS vasculitis and were included. The clinical presentation was variable, but the most common complaints were headache in 18, focal deficits in 9, disturbances of consciousness in 9, and seizures in 8 patients. Underlying causes for CNS vasculitis were identified in all patients and included systemic lupus erythematosus in eight, tuberculosis in three, bacterial meningitis in three, Takayasu arteritis in two, polyarteritis nodosa in two, syphilis in two, drug abuse in two, yellow fever in one and varicella in one patient. Nonspecific high intensity T2WI/FLAIR lesions in white matter were the most common finding, present in ten patients. Eight patients had infarctions in large cerebral arteries territory, associated or not with high intensity T2WI/FLAIR small foci. Vascular involvement of the CNS can be found in a great variety of systemic diseases, including rheumatologic, infectious and drug abuse. Clinical findings are unspecific and MRI/MRA may help to establish the correct diagnosis.

AB - The objective of this study was to review magnetic resonance imaging (MRI) findings in patients with vascular involvement of the central nervous system (CNS) associated with systemic diseases. We reviewed the MRI findings in clinically suspected cases of vascular involvement of the CNS associated with systemic diseases. Vascular CNS involvement was considered in the presence of characteristic clinical, MRI and/or MR angiography findings. In order to be included in the study, patients needed to have a complete clinical and laboratory investigation and a follow-up of a minimum of 6 months. Twenty-four patients (17 women and 7 men), with mean age of 29.5 years had diagnosis of CNS vasculitis and were included. The clinical presentation was variable, but the most common complaints were headache in 18, focal deficits in 9, disturbances of consciousness in 9, and seizures in 8 patients. Underlying causes for CNS vasculitis were identified in all patients and included systemic lupus erythematosus in eight, tuberculosis in three, bacterial meningitis in three, Takayasu arteritis in two, polyarteritis nodosa in two, syphilis in two, drug abuse in two, yellow fever in one and varicella in one patient. Nonspecific high intensity T2WI/FLAIR lesions in white matter were the most common finding, present in ten patients. Eight patients had infarctions in large cerebral arteries territory, associated or not with high intensity T2WI/FLAIR small foci. Vascular involvement of the CNS can be found in a great variety of systemic diseases, including rheumatologic, infectious and drug abuse. Clinical findings are unspecific and MRI/MRA may help to establish the correct diagnosis.

KW - Central nervous system

KW - Magnetic resonance imaging

KW - Vaculitis

UR - http://www.scopus.com/inward/record.url?scp=51649116574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51649116574&partnerID=8YFLogxK

U2 - 10.1007/s00296-008-0647-z

DO - 10.1007/s00296-008-0647-z

M3 - Article

C2 - 18651146

AN - SCOPUS:51649116574

VL - 28

SP - 1229

EP - 1237

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 12

ER -