Vascular gene therapy

M. Y. Flugelman, M. Parmacek, Brian O'Rourke, W. Barry, H. E D J Ter Keurs, M. Lab, R. Reneman, R. Beyar

Research output: Contribution to journalArticle

Abstract

Gene therapy is emerging as a new and exciting therapeutic modality for cardiovascular pathology. The work reported here was carried out in the National Heart, Lung and Blood Institute (NHLBI) in Bethesda, MD, USA, where genetically engineered endothelial cells were used to seed endovascular prostheses and cell adhesion to the prostheses was tested both in vitro and in vivo. Two catheter based systems were used to deliver genes to the arterial wall cells in vivo, employing retroviral and adenoviral vectors. Efficient gene transfer to vascular cells in vivo was achieved with adenoviral vectors.

Original languageEnglish (US)
Pages (from-to)269-277
Number of pages9
JournalAdvances in Experimental Medicine and Biology
Volume382
StatePublished - 1995
Externally publishedYes

Fingerprint

Gene therapy
Prosthetics
Genetic Therapy
Prostheses and Implants
Blood Vessels
National Heart, Lung, and Blood Institute (U.S.)
Gene transfer
Catheters
Cell adhesion
Endothelial cells
Pathology
Cell Adhesion
Cell Wall
Genes
Seed
Seeds
Blood
Endothelial Cells
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Flugelman, M. Y., Parmacek, M., O'Rourke, B., Barry, W., Ter Keurs, H. E. D. J., Lab, M., ... Beyar, R. (1995). Vascular gene therapy. Advances in Experimental Medicine and Biology, 382, 269-277.

Vascular gene therapy. / Flugelman, M. Y.; Parmacek, M.; O'Rourke, Brian; Barry, W.; Ter Keurs, H. E D J; Lab, M.; Reneman, R.; Beyar, R.

In: Advances in Experimental Medicine and Biology, Vol. 382, 1995, p. 269-277.

Research output: Contribution to journalArticle

Flugelman, MY, Parmacek, M, O'Rourke, B, Barry, W, Ter Keurs, HEDJ, Lab, M, Reneman, R & Beyar, R 1995, 'Vascular gene therapy', Advances in Experimental Medicine and Biology, vol. 382, pp. 269-277.
Flugelman MY, Parmacek M, O'Rourke B, Barry W, Ter Keurs HEDJ, Lab M et al. Vascular gene therapy. Advances in Experimental Medicine and Biology. 1995;382:269-277.
Flugelman, M. Y. ; Parmacek, M. ; O'Rourke, Brian ; Barry, W. ; Ter Keurs, H. E D J ; Lab, M. ; Reneman, R. ; Beyar, R. / Vascular gene therapy. In: Advances in Experimental Medicine and Biology. 1995 ; Vol. 382. pp. 269-277.
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