Vascular endothelial growth factor in heart failure

Ziad Taimeh, John Loughran, Emma J. Birks, Roberto Bolli

Research output: Contribution to journalReview article

Abstract

Heart failure is a devastating condition, the progression of which culminates in a mismatch of oxygen supply and demand, with limited options for treatment. Heart failure has several underlying causes including, but not limited to, ischaemic heart disease, valvular dysfunction, and hypertensive heart disease. Dysfunctional blood vessel formation is a major problem in advanced heart failure, regardless of the aetiology. Vascular endothelial growth factor (VEGF) is the cornerstone cytokine involved in the formation of new vessels. A multitude of investigations, at both the preclinical and clinical levels, have garnered valuable information on the potential utility of targeting VEGF as a treatment option for heart failure. However, clinical trials of VEGF gene therapy in patients with coronary artery disease or peripheral artery disease have not, to date, demonstrated clinical benefit. In this Review, we outline the biological characterization of VEGF, and examine the evidence for its potential therapeutic application, including the novel concept of VEGF as adjuvant therapy to stem cell transplantation, in patients with heart failure.

Original languageEnglish (US)
Pages (from-to)519-530
Number of pages12
JournalNature Reviews Cardiology
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Taimeh, Z., Loughran, J., Birks, E. J., & Bolli, R. (2013). Vascular endothelial growth factor in heart failure. Nature Reviews Cardiology, 10(9), 519-530. https://doi.org/10.1038/nrcardio.2013.94