Vascular effects of 2-chloroprocaine and sodium metabisulfite on isolated rat aortic rings

Michael H. Wills, Jeffrey C. Moscicki, Roger A. Johns, Cosmo A. Difazio, David J. Stone

Research output: Contribution to journalArticlepeer-review

Abstract

Neurologic deficits have followed the intrathecal injection of 2-chIoroprocaine 3% (IO-1 M) with sodium metabisulfite 0.2% (IO-2 M) as a preservative. This study evaluated the effects of varying concentrations of 2-chIoroprocaine and sodium metabisulfite, as well as the combination of the two, on the vascular reactivity of isolated rings of rat thoracic aorta. Isolated Sprague-Dawley rat thoracic aortic rings were prepared and connected to force transducers for measurement of isometric tension. The tension produced by logarithmically increasing concentrations of 2-chloroprocaine, sodium metabisulfite, and their paired combination was measured. Sodium metabisulfite concentrations below 0.2% (10∼z M) caused a maximum of 40% vasoconstriction compared to control followed by vasodilation with a maximum of 80% at 10∼2 M (the concentration in the former clinical preparation). 2-chloroprocaine alone produced a progressive relaxation at IO-3 M or higher concentration with a maximum of 130%. The effects of the mixture of sodium metabisulfite and 2-chloroprocaine were identical to the effects produced by 2-chloroprocaine alone. The relaxation effects of 2-chloroprocaine dominate the vasoconstricting effects of sodium metabisulfite when the two drugs are combined.

Original languageEnglish (US)
Pages (from-to)271-273
Number of pages3
JournalRegional Anesthesia
Volume14
Issue number6
StatePublished - 1989
Externally publishedYes

Keywords

  • Anesthetic techniques
  • Chloroprocaine
  • Complications
  • Epidural
  • Local anesthetics
  • Metabisulfite
  • Toxicity

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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