TY - JOUR
T1 - Vascular Disease and Future Risk of Depressive Symptomatology in Older Adults
T2 - Findings from the Health, Aging, and Body Composition Study
AU - Mast, Benjamin T.
AU - Miles, Toni
AU - Penninx, Brenda W.
AU - Yaffe, Kristine
AU - Rosano, Caterina
AU - Satterfield, Suzanne
AU - Ayonayon, Hilsa N.
AU - Harris, Tamara
AU - Simonsick, Eleanor M.
N1 - Funding Information:
The Health ABC study was funded by the National Institute on Aging (N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106). The work of Dr. Penninx is supported through National Institutes of Health (NIH) Grant R01-HL972972. This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging. We wish to thank Sarah Rowe for her assistance in preparing this manuscript. The authors have no biomedical financial interests or potential conflicts of interest related to this study.
PY - 2008/8/15
Y1 - 2008/8/15
N2 - Background: The vascular depression hypothesis suggests that age-related vascular diseases and risk factors contribute to late-life depression. Although neuroimaging studies provide evidence for an association between depression and severity of vascular lesions in the brain, studies of depression and indicators of vascular risk have been less consistent. Methods: We examined 1796 elders ages 70-79 from the Health, Aging and Body Composition study without depression at baseline and examined the association between prevalent vascular disease and related conditions at baseline and 2-year incidence of elevated depressive symptoms, defined as a score > 8 on the 10-item Center for Epidemiologic Studies Depression (CES-D) scale. Results: After adjustment for demographic data and physical and cognitive functioning, several vascular conditions remained associated with increased risk of depressive symptomatology including metabolic syndrome and its components (low high-density lipoprotein cholesterol and high fasting glucose), coronary heart disease, a positive Rose questionnaire for angina, and high hemoglobin a1c. Cumulative vascular risk based upon a composite of 10 vascular diseases and risk factors was independently associated with incident elevated depression at 2-year follow-up after controlling for demographic data, physical and cognitive functioning, and selected comorbid medical conditions. Conclusions: These results provide support for the vascular depression hypothesis in demonstrating an association between vascular conditions and risk factors and subsequent risk of depressive symptomatology. Older adults with vascular conditions and risk factors require close monitoring of depressive symptoms.
AB - Background: The vascular depression hypothesis suggests that age-related vascular diseases and risk factors contribute to late-life depression. Although neuroimaging studies provide evidence for an association between depression and severity of vascular lesions in the brain, studies of depression and indicators of vascular risk have been less consistent. Methods: We examined 1796 elders ages 70-79 from the Health, Aging and Body Composition study without depression at baseline and examined the association between prevalent vascular disease and related conditions at baseline and 2-year incidence of elevated depressive symptoms, defined as a score > 8 on the 10-item Center for Epidemiologic Studies Depression (CES-D) scale. Results: After adjustment for demographic data and physical and cognitive functioning, several vascular conditions remained associated with increased risk of depressive symptomatology including metabolic syndrome and its components (low high-density lipoprotein cholesterol and high fasting glucose), coronary heart disease, a positive Rose questionnaire for angina, and high hemoglobin a1c. Cumulative vascular risk based upon a composite of 10 vascular diseases and risk factors was independently associated with incident elevated depression at 2-year follow-up after controlling for demographic data, physical and cognitive functioning, and selected comorbid medical conditions. Conclusions: These results provide support for the vascular depression hypothesis in demonstrating an association between vascular conditions and risk factors and subsequent risk of depressive symptomatology. Older adults with vascular conditions and risk factors require close monitoring of depressive symptoms.
KW - Cerebrovascular disease
KW - geriatric depression
KW - vascular depression
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U2 - 10.1016/j.biopsych.2008.01.025
DO - 10.1016/j.biopsych.2008.01.025
M3 - Article
C2 - 18367153
AN - SCOPUS:48149099756
SN - 0006-3223
VL - 64
SP - 320
EP - 326
JO - Biological psychiatry
JF - Biological psychiatry
IS - 4
ER -