Vascular cognitive impairment

Ola A. Selnes, Harry V. Vinters

Research output: Contribution to journalArticle

Abstract

Cognitive impairment commonly accompanies clinical syndromes associated with vascular disease of the brain. Because of evolving definitional criteria, however, the frequency of cognitive impairment attributable to cerebrovascular disease is difficult to determine. Dementia occurs in up to one-third of elderly patients with stroke, a subset of whom have Alzheimer's disease (AD) rather than a pure vascular dementia syndrome. In fact, pure vascular dementia has been shown to be uncommon in most large autopsy series. A mixed etiology of AD and cerebrovascular disease is thought to become more common with increasing age, although no clinical criteria for the diagnosis of AD with cerebrovascular disease are currently available. Epidemiological studies have implicated subcortical small-vessel disease as a risk factor for cognitive impairment and dementia, but the cognitive expression and clinical significance of MRI white matter changes in individual patients is difficult to establish. The frequency of specific neuropathologic features of vascular cognitive impairment depends largely on study inclusion criteria. Cerebral meningocortical microangiopathies with distinctive clinicopathological profiles are associated with dementia in both sporadic cases and familial syndromes. In patients with AD, the contribution of amyloid-β protein to the degree of cognitive impairment has not been clearly defined.

Original languageEnglish (US)
Pages (from-to)538-547
Number of pages10
JournalNature Clinical Practice Neurology
Volume2
Issue number10
DOIs
StatePublished - Oct 2006

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Blood Vessels
Cerebrovascular Disorders
Alzheimer Disease
Dementia
Vascular Dementia
Cerebral Small Vessel Diseases
Amyloidogenic Proteins
Vascular Diseases
Epidemiologic Studies
Autopsy
Stroke
Cognitive Dysfunction
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vascular cognitive impairment. / Selnes, Ola A.; Vinters, Harry V.

In: Nature Clinical Practice Neurology, Vol. 2, No. 10, 10.2006, p. 538-547.

Research output: Contribution to journalArticle

Selnes, OA & Vinters, HV 2006, 'Vascular cognitive impairment', Nature Clinical Practice Neurology, vol. 2, no. 10, pp. 538-547. https://doi.org/10.1038/ncpneuro0294
Selnes, Ola A. ; Vinters, Harry V. / Vascular cognitive impairment. In: Nature Clinical Practice Neurology. 2006 ; Vol. 2, No. 10. pp. 538-547.
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