Vascular calcification in patients with large-vessel vasculitis compared to patients with hyperlipidemia

Shubhasree Banerjee, Mohammadhadi Bagheri, Veit Sandfort, Mark A. Ahlman, Ashkan A. Malayeri, David Alan Bluemke, Jianhua Yao, Peter C. Grayson

Research output: Contribution to journalArticle

Abstract

Objective: Calcification of the coronary arteries, aorta, and branch vessels can occur in both large-vessel vasculitis (LVV)and atherosclerosis. The study objective was to determine the location and amount of vascular calcification in patients with LVV versus hyperlipidemia (HLD)and to identify risk factors associated with vascular calcification in LVV. Methods: Patients with giant cell arteritis (GCA), Takayasu's arteritis (TAK), and HLD underwent non-contrast computed tomography of the aorta and branch vessels. Vascular calcification in 14 specific arterial territories (4 segments of the aorta, 9 branch arteries, and the coronary arteries)was quantified throughout the large arteries by a cumulative Agatston score. Multivariate linear regression analyses were used to identify associations between traditional and disease-specific risk factors and total Agatston score. Results: A total of 88 subjects, including GCA (n = 29); TAK (n = 22); and HLD (n = 37), participated. Prevalence of vascular calcification in the aorta and branch vessels significantly differed in the coronary arteries (HLD = 67%, GCA = 35%, TAK = 9%, p < 0.01). Total Agatston scores were higher in GCA (median 3260, range 25–18,138)versus HLD (460, 19–17,215)(p < 0.01)but did not significantly differ between GCA and TAK (1944, 52–47,520)(p = 0.53). In multivariable regression analysis, age, type of vasculitis, and prednisone use was associated with vascular calcification in LVV. Conclusion: The prevalence of coronary artery calcification is lower in LVV compared to HLD, but the amount of total vascular calcification throughout the large arteries is greater in LVV. Both traditional and disease-specific risk factors are associated with vascular calcification in LVV.

Original languageEnglish (US)
Pages (from-to)1068-1073
Number of pages6
JournalSeminars in Arthritis and Rheumatism
Volume48
Issue number6
DOIs
StatePublished - Jun 2019
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Giant cell arteritis
  • Hyperlipidemia
  • Large-vessel vasculitis
  • Takayasu's arteritis
  • Vascular calcification

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Vascular calcification in patients with large-vessel vasculitis compared to patients with hyperlipidemia'. Together they form a unique fingerprint.

  • Cite this