Vascular abnormalities in primary amyloidosis

Karen M. Modesto, Angela Dispenzieri, Morie Gertz, Sanderson A. Cauduro, Bijoy K. Khandheria, James B. Seward, Robert Kyle, Christina M. Wood, Kent R. Bailey, Abdel Jamil Tajik, Fletcher A. Miller, Patricia A. Pellikka, Theodore P. Abraham

Research output: Contribution to journalArticle

Abstract

Aims: Primary amyloidosis (AL) is a systemic disease; however, there is limited information regarding the presence and character of vascular abnormalities. Methods and results: Validated ultrasound techniques were used to prospectively determine carotid artery intimal-medial thickness (IMT) and brachial artery flow-mediated dilatation (FMD) in 59 consecutive AL patients and 17 age-similar, healthy, asymptomatic volunteers (CON). Carotid IMT was increased in AL when compared with CON (0.07 ± 0.02 vs. 0.04 ± 0.01 mm, P < 0.01). Similarly, brachial artery FMD was significantly lower in AL when compared with CON subjects (3 ± 7 vs. 12 ± 8%, P < 0.01). Multivariable analysis revealed that AL was associated with larger IMT and lower FMD after controlling for several confounding variables. However, within AL cases, there was not a significant association of cardiac vs. non-cardiac involvement with IMT or FMD (P = 0.1 and 0.2, respectively). Conclusion: AL is associated with abnormal vascular morphology and endothelial dysfunction. Vascular abnormalities do not appear to be related to echocardiographic evidence of cardiac involvement.

Original languageEnglish (US)
Pages (from-to)1019-1024
Number of pages6
JournalEuropean heart journal
Volume28
Issue number8
DOIs
StatePublished - Apr 1 2007

Keywords

  • Amyloidosis
  • Endothelial function
  • Flow-mediated arterial dilatation
  • Intimal-medial thickness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Modesto, K. M., Dispenzieri, A., Gertz, M., Cauduro, S. A., Khandheria, B. K., Seward, J. B., Kyle, R., Wood, C. M., Bailey, K. R., Tajik, A. J., Miller, F. A., Pellikka, P. A., & Abraham, T. P. (2007). Vascular abnormalities in primary amyloidosis. European heart journal, 28(8), 1019-1024. https://doi.org/10.1093/eurheartj/ehm066